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A total of 836 patients with type 2 diabetes taking oral antidiabetic drugs with glycated hemoglobin (HbA1c) &gt;7% entered the study. Basal insulin was given for 24 weeks. All treatment choices and medical instructions were at the physician's discretion to reflect real\u2010life practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 24\u2010week treatment, 11.7% of patients reached set HbA1c goals without severe hypoglycemia (primary effectiveness end\u2010point). HbA1c and fasting blood glucose were significantly decreased from (mean \u00b1 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 10.1 \u00b1 1.9% to 8.7 \u00b1 1.7% (\u22121.4 \u00b1 2.1%, <jats:italic>P<\/jats:italic> &lt; 0.0001) and from 230.6 \u00b1 68.8 mg\/dL to 159.1 \u00b1 55.6 mg\/dL (\u221267.4 \u00b1 72.3 mg\/dL, <jats:italic>P<\/jats:italic> &lt; 0.0001), respectively. Patients received insulin therapy at a frequency of nearly one shot per day on average, whereas self\u2010monitoring of blood glucose was carried out approximately four times a week. Hypoglycemia was reported by 11.4% of patients, and only 0.7% of patients experienced severe hypoglycemia. Slight changes in weight (0.7 \u00b1 2.4 kg) and a low incidence of adverse drug reactions (0.4%) were also noted. The score of 7\u2010point treatment satisfaction rated by patients was significantly improved by 1.9 \u00b1 1.7 (<jats:italic>P<\/jats:italic> &lt; 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Basal insulin therapy was associated with a decrease in HbA1c and fasting blood glucose, and an improved treatment satisfaction. Most patients complied with physicians' instructions. The treatment was generally well tolerated by patients with type 2 diabetes, but findings pointed out the need to reinforce the early and appropriate uptitration to achieve treatment targets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12532","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T20:04:32Z","timestamp":1461701072000},"page":"881-888","source":"Crossref","is-referenced-by-count":12,"title":["Glycemic control and adherence to basal insulin therapy in Taiwanese patients with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"7","author":[{"given":"Ming\u2010Nan","family":"Chien","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan"},{"name":"Department of Medicine Mackay Medical College New Taipei City Taiwan"},{"name":"Institute of Mechatronic Engineering National Taipei University of Technology Taipei 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