{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:41:21Z","timestamp":1769146881040,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,9]],"date-time":"2016-07-09T00:00:00Z","timestamp":1468022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300666"],"award-info":[{"award-number":["81300666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170760"],"award-info":[{"award-number":["81170760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200582"],"award-info":[{"award-number":["81200582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Previous studies have suggested a possible relationship between type 2 diabetes mellitus susceptibility loci and diabetic complications. The present study aimed to investigate the associations between type 2 diabetes mellitus loci with peripheral nerve function in a Chinese population with type 2 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 1,900 type 2 diabetes mellitus patients were recruited in the study. We selected ten single nucleotide polymorphisms (SNPs) from ten type 2 diabetes mellitus susceptibility genes previously confirmed in Chinese patients. Genotyping was carried out by using a Mass<jats:styled-content style=\"fixed-case\">ARRAY<\/jats:styled-content> Compact Analyzer. Peripheral nerve function was evaluated by nerve conduction studies in all participants. The composite <jats:italic>Z<\/jats:italic>\u2010scores for nerve conduction parameters including conduction velocity (CV), amplitude and latency were calculated, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rs5219 of <jats:italic><jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>11<\/jats:italic> (E23K, G\u2192A) was identified to be associated with all the parameters obtained from nerve conduction studies (<jats:italic>Z<\/jats:italic>\u2010score of CV: \u03b2 = 0.113, <jats:italic>P<\/jats:italic> = 0.01; <jats:italic>Z<\/jats:italic>\u2010score of amplitude: \u03b2 = 0.133, <jats:italic>P<\/jats:italic> = 0.01; <jats:italic>Z<\/jats:italic>\u2010score of latency: \u03b2 = \u22120.116, <jats:italic>P<\/jats:italic> = 0.01) after adjustment for covariates including age, duration and glycated hemoglobin. Specifically, each copy of the A allele was related to better outcomes. <jats:italic><jats:styled-content style=\"fixed-case\">CDKAL<\/jats:styled-content>1<\/jats:italic> rs7756992 and <jats:italic><jats:styled-content style=\"fixed-case\">TCF<\/jats:styled-content>7L2<\/jats:italic> rs7903146 correlated with the composite <jats:italic>Z<\/jats:italic>\u2010score of amplitude (<jats:italic>P<\/jats:italic> = 0.028 and <jats:italic>P<\/jats:italic> = 0.016, respectively), but not CV (<jats:italic>P<\/jats:italic> = 0.393 and <jats:italic>P<\/jats:italic> = 0.281, respectively) or latency (<jats:italic>P<\/jats:italic> = 0.286 and <jats:italic>P<\/jats:italic> = 0.273, respectively). There were no significant associations between the other seven SNPs and peripheral nerve function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Rs5219 at <jats:italic><jats:styled-content style=\"fixed-case\">KCNJ<\/jats:styled-content>11<\/jats:italic> (E23K) was associated with peripheral nerve function in a Chinese population with type 2 diabetes mellitus, suggesting shared genetic factors for type 2 diabetes mellitus and diabetic polyneuropathy in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12546","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T13:27:09Z","timestamp":1464874029000},"page":"115-120","source":"Crossref","is-referenced-by-count":13,"title":["Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"},{"name":"Shanghai Diabetes Institute Shanghai China"},{"name":"Shanghai Key Laboratory of Diabetes Mellitus Shanghai China"},{"name":"Shanghai Clinical Center for Diabetes Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China"},{"name":"Shanghai Diabetes Institute Shanghai China"},{"name":"Shanghai Key Laboratory of Diabetes Mellitus Shanghai China"},{"name":"Shanghai Clinical Center for Diabetes Shanghai 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