{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:47:24Z","timestamp":1724413644910},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The pathophysiology of diabetes differs between Asian and Western patients in many ways, and diet is a primary contributor. The present study examined the effect of diet on the efficacy of 25% insulin lispro\/75% insulin lispro protamine suspension (<jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>25) and 50% insulin lispro\/50% insulin lispro protamine suspension (<jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>50) as starter insulin in Chinese and Japanese patients with type 2 diabetes and inadequate glycemic control with oral antidiabetic medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a predefined subgroup analysis of a phase 4, open\u2010label, 26\u2010week, parallel\u2010arm, randomized (computer\u2010generated random sequence) trial (21 January 2013 to 22 August 2014). Nutritional intake was assessed from food records kept by participants before study drug administration. Outcomes assessed were changes from baseline in self\u2010monitored blood glucose, 1,5\u2010anhydroglucitol and glycated hemoglobin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 328 participants were randomized to receive twice\u2010daily <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>25 (<jats:italic>n<\/jats:italic> = 168) or <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>50 (<jats:italic>n<\/jats:italic> = 160). Median daily nutritional intake (by weight and percentage of total energy) was 230.8 g of carbohydrate (54%), 56.5 g of fat (31%) and 66 g of protein (15%). Improvements in self\u2010monitored blood glucose were significantly greater (<jats:italic>P<\/jats:italic> \u2264 0.028) in the <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>50 group than in the <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>25 group, regardless of nutritional intake. When carbohydrate (by weight or percentage energy) or fat (by weight) intake exceeded median levels, <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>50 was significantly more efficacious than <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>25 (<jats:italic>P<\/jats:italic> \u2264 0.026) in improving 1,5\u2010anhydroglucitol and glycated hemoglobin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Glycemic control improved in both <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>25 and <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>50 groups, but <jats:styled-content style=\"fixed-case\">LM<\/jats:styled-content>50 was significantly more efficacious under certain dietary conditions, particularly with increased carbohydrate intake.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12547","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T08:15:09Z","timestamp":1465632909000},"page":"75-83","source":"Crossref","is-referenced-by-count":3,"title":["Impact of diet on the efficacy of insulin lispro mix 25 and insulin lispro mix 50 as starter insulin in East Asian patients with type 2 diabetes: Subgroup analysis of the Comparison Between Low Mixed Insulin and Mid Mixed Insulin as Starter Insulin For Patients with Type 2 Diabetes Mellitus (<scp>CLASSIFY<\/scp> Study) randomized trial"],"prefix":"10.1111","volume":"8","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Parenteral and Enteral Nutrition Peking Union Medical College Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qian","sequence":"additional","affiliation":[{"name":"Medical Department Lilly Suzhou Pharmaceutical Co. Ltd Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Watada","sequence":"additional","affiliation":[{"name":"Department of Metabolism &amp; Endocrinology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Department Lilly Suzhou Pharmaceutical Co. Ltd Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Medicines Development Unit Japan Eli Lilly Japan K.K. Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Imori","sequence":"additional","affiliation":[{"name":"Medicines Development Unit Japan Eli Lilly Japan K.K. Kobe Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology China\u2010Japan Friendship Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908292"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12136"},{"key":"e_1_2_7_4_1","unstructured":"International Diabetes Federation.IDF Diabetes Atlas \u2010 sixth edition.2014. 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