{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:54:14Z","timestamp":1771653254115,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,30]],"date-time":"2017-03-30T00:00:00Z","timestamp":1490832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Korean Health Technology R&D Project","award":["HI14C2750"],"award-info":[{"award-number":["HI14C2750"]}]},{"name":"Ministry of Health & Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To assess the time to initiation of insulin therapy, and concurrently investigate both patient\u2010 and physician\u2010related factors associated with delaying insulin therapy in Korean patients with type 2 diabetes uncontrolled by oral hypoglycemic agents (OHAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective, observational disease registry study was carried out across 69 centers in Korea. Type 2 diabetes patients who had received two or more OHAs within the past 5\u00a0years, had a glycated hemoglobin \u22658% in the past 6\u00a0months and had not received insulin were included. Data recorded on data collection forms during a 12\u2010month period were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2168 patients enrolled, 1959 were evaluated and classified as the insulin\u2010initiated or insulin\u2010delayed group. Insulin was prescribed for just 20% of the patients during a 1\u2010year follow\u2010up period, and less than half (44.5%) of the patients who were taking two OHAs started insulin after 6\u00a0years. Patient\u2010related factors for delay in insulin initiation included older age, shorter duration of diabetes and lower glycated hemoglobin. Physician\u2010related factors included age (~50 to &lt;60\u00a0years), sex (women) and number (&lt;1000) of patients consulted per month. Patient refusal (33.6%) and physicians\u2019 concerns of patient non\u2010compliance (26.5%) were the major physician\u2010reported reasons for delaying insulin therapy. Inconvenience of insulin therapy (51.6%) and fear of injection (48.2%) were the major reasons for patient refusal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Insulin initiation is delayed in patients with type 2 diabetes uncontrolled by two or more OHAs in Korea. Patient\u2010 and physician\u2010related factors associated with this delay need to be addressed for better diabetes management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12581","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:56:55Z","timestamp":1476320215000},"page":"346-353","source":"Crossref","is-referenced-by-count":35,"title":["Delay of insulin initiation in patients with type 2 diabetes mellitus inadequately controlled with oral hypoglycemic agents (analysis of patient\u2010 and physician\u2010related factors): A prospective observational DIPP\u2010FACTOR study in Korea"],"prefix":"10.1111","volume":"8","author":[{"given":"Sin Gon","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Endocrinology Korea University Anam Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Korea University Anam Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-8949","authenticated-orcid":false,"given":"Bon Jeong","family":"Ku","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chungnam National University Hospital Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Sang","family":"Shon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Catholic University of Daegu School of Medicine Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo Man","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Hallym University Kangdong Sacred Heart Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Sun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Chonbuk National University Medical School Jeonju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Seong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology &amp; Metabolism Department of Internal Medicine Inha University Incheon Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Pusan National University Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Seop","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Korea University Anam Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"IDF Diabetes Atlas Sixth Edition [Internet]. International Diabetes Federation; 2013. Available from:http:\/\/www.idf.org\/worlddiabetesday\/toolkit\/gp\/facts-figuresAccessed August 22 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2011.35.4.303"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2014.38.3.197"},{"key":"e_1_2_7_5_1","unstructured":"Statistics Korea: statistical results about cause of death [Internet]; 2009. 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