{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T05:26:40Z","timestamp":1696656400201},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,25]],"date-time":"2016-11-25T00:00:00Z","timestamp":1480032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Medical Science Foundation of Fudan University Huashan Hospital"},{"name":"Clinical Medicine Foundation of Shanghai Tongji Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The purpose of the present study was to investigate the severity of glucose profiles and \u03b2\u2010cell function associated with diabetic cardiovascular autonomic neuropathy (<jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content>) in a Chinese sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A community\u2010based, cross\u2010sectional study to analyze the risk factors of <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content> was carried out with 455 individuals recruited from a Chinese population. The glucose profile risk score was calculated to identify the association between the severity of the glucose profiles and <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content>. The associations of the severity of the glucose profiles and \u03b2\u2010cell function with <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content> were analyzed using multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis showed that the glucose profiles and homeostatic model assessment of insulin resistance were significantly associated with the <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content> outcome, respectively. Multivariable logistic regression showed that significant associations exist between glucose profile indices and <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content>, after controlling for potential confounding factors (<jats:italic>P<\/jats:italic> &lt; 0.01 for all) in both models. Multivariable logistic regression also showed that parameters of \u03b2\u2010cell function were associated with the <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content> outcome in the category model (<jats:italic>P<\/jats:italic> &lt; 0.1 for all). The glucose profile risk score was independently and significantly associated with the <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content> outcome after controlling for confounding factors (<jats:italic>P<\/jats:italic> &lt; 0.001 and <jats:italic>P<\/jats:italic> for a trend &lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our observations suggest that parameters of glucose profile indices and \u03b2\u2010cell function are significantly and independently associated with <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content>, respectively. There was a tendency toward increased glucose profile risk score with increasing prevalence of <jats:styled-content style=\"fixed-case\">DCAN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12584","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T02:37:25Z","timestamp":1476412645000},"page":"354-362","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of the association between glucose profiles and \u03b2\u2010cell function for diabetic cardiovascular autonomic neuropathy in <scp>C<\/scp>hina"],"prefix":"10.1111","volume":"8","author":[{"given":"Ping","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Integrative Medicine Huashan Hospital Fudan University Shanghai China"},{"name":"Department of Endocrinology Shanghai Tongji Hospital Tongji University Shanghai 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