{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:01:42Z","timestamp":1790827302037,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T00:00:00Z","timestamp":1483660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 27\u2010year\u2010old woman with panic disorder taking 20\u00a0mg olanzapine daily for 4\u00a0months was admitted to Mito Kyodo General Hospital, Mito, Ibaraki, Japan, because of disturbed consciousness with fever, hyperglycemia, hyperosmolarity and elevated creatine phosphokinase. She was diagnosed with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome. Brain magnetic resonance imaging showed transiently restricted diffusion in the splenium of the corpus callosum, with a high signal intensity on diffusion\u2010weighted imaging. The neurological abnormalities disappeared along with improvement of metabolic derangements, and the follow\u2010up magnetic resonance imaging carried out on the 26th day of admission showed complete resolution of the lesions in the splenium of the corpus callosum. These clinical and radiological features are highly suggestive of clinically mild encephalitis\/encephalopathy with a reversible splenial lesion. The first case of mild encephalitis\/encephalopathy with a reversible splenial lesion caused by olanzapine\u2010induced hyperosmolar hyperglycemic state and neuroleptic malignant syndrome is reported.<\/jats:p>","DOI":"10.1111\/jdi.12597","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T17:16:38Z","timestamp":1479489398000},"page":"392-394","source":"Crossref","is-referenced-by-count":23,"title":["Reversible splenial lesion syndrome with a hyperosmolar hyperglycemic state and neuroleptic malignant syndrome caused by olanzapine"],"prefix":"10.1111","volume":"8","author":[{"given":"Kenta","family":"Kaino","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Tsukuba University Hospital Mito Clinical Education and Training Center Mito Kyodo General Hospital Mito Ibaraki 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