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As a result, pancreatic \u03b2\u2010cell function and peripheral insulin action significantly improve with relief from glucose toxicity. Furthermore, whole\u2010body energy metabolism changes to relative glucose deficiency and triggers increased lipolysis in fat cells, and fatty acid oxidation and then ketone body production in the liver during treatment with\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors. In addition,\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors have profound hemodynamic effects including diuresis, dehydration, weight loss and lowering blood pressure. The most recent findings on\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors come from results of the Empagliflozin, Cardiovascular Outcomes and Mortality in Type 2 Diabetes trial.\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors exert extremely unique and cardio\u2010renal protection through metabolic and hemodynamic effects, with long\u2010term durability on the reduction of blood glucose, bodyweight and blood pressure. Although a site of action of\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors is highly specific to inhibit renal glucose reabsorption, whole\u2010body energy metabolism, and hemodynamic and renal functions are profoundly modulated during the treatment of\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors. Previous studies suggest multifactorial clinical benefits and safety concerns of\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors. Although ambivalent clinical results of this drug are still under active discussion, the present review summarizes promising recent evidence on the cardio\u2010renal and metabolic benefits of\n                    <jats:styled-content style=\"fixed-case\">SGLT<\/jats:styled-content>\n                    2 inhibitors in the treatment of type 2 diabetes.\n                  <\/jats:p>","DOI":"10.1111\/jdi.12644","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T16:36:39Z","timestamp":1486571799000},"page":"416-427","source":"Crossref","is-referenced-by-count":65,"title":["Metabolic and hemodynamic effects of sodium\u2010dependent glucose cotransporter 2 inhibitors on cardio\u2010renal protection in the treatment of patients with type 2 diabetes mellitus"],"prefix":"10.1111","volume":"8","author":[{"given":"Atsunori","family":"Kashiwagi","sequence":"first","affiliation":[{"name":"Kusatsu General Hospital Kusatsu 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