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Altered FoxO1 expression and activity have been associated with glucose intolerance, dyslipidemia and complications of diabetes. In the liver, they direct carbons to glucose or lipid utilization, thus providing a unifying mechanism for the two abnormalities of the diabetic liver: excessive glucose production, and increased lipid synthesis and secretion. In the pancreas, FoxO1 is necessary to maintain \u03b2\u2010cell differentiation, and could be promising targets for \u03b2\u2010cell regeneration. In endothelial cells, FoxOs strongly promote atherosclerosis through suppressing nitric oxide production and enhancing inflammatory responses. In the present review, we summarize the basic biology and pathophysiological significance of FoxOs in diabetes.<\/jats:p>","DOI":"10.1111\/jdi.12651","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T15:33:20Z","timestamp":1488900800000},"page":"726-734","source":"Crossref","is-referenced-by-count":51,"title":["Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes"],"prefix":"10.1111","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-1018","authenticated-orcid":false,"given":"Kyoichiro","family":"Tsuchiya","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Metabolism Medical Hospital of Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Medicine and Bioregulatory Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Japan Agency for Medical Research and Development CREST Tokyo 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