{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:38:51Z","timestamp":1784605131611,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71373160"],"award-info":[{"award-number":["71373160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300603"],"award-info":[{"award-number":["81300603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Diabetic kidney disease (<jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content>) is the second leading cause (16.4%) of end\u2010stage renal disease in China. The current study assessed the cost\u2010effectiveness of preventing<jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content>in patients with newly diagnosed type 2 diabetes from the Chinese healthcare perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A lifetime Markov decision model was developed according to the disease course of<jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content>. Patients with newly diagnosed type 2 diabetes might receive treatment according to one of the following three strategies: (i) \u201cdo nothing\u201d strategy (control strategy); (ii) treatment with angiotensin\u2010converting enzyme inhibitors and angiotensin<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>receptor blockers (universal strategy); (iii) or screening for microalbuminuria followed by angiotensin\u2010converting enzyme inhibitor\/angiotensin<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>receptor blocker treatment (screening strategy). Clinical and utility data were obtained from the published literature. Direct medical costs and resource utilization in the Chinese healthcare setting were considered. Sensitivity analyses were undertaken to test the impact of a range of variables and assumptions on the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control strategy, both the screening and universal strategies were cost\u2010saving options that showed lower costs and better health benefits. The incremental cost\u2010effectiveness ratio of the universal strategy over the screening strategy was<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$30,087 per quality\u2010adjusted life\u2010year, which was higher than the cost\u2010effectiveness threshold of China. The sensitivity analyses showed robust results, except for the probability of developing macroalbuminuria from microalbuminuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Screening for microalbuminuria could be a cost\u2010saving option for the prevention of<jats:styled-content style=\"fixed-case\">DKD<\/jats:styled-content>in the Chinese setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12653","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T23:03:01Z","timestamp":1489186981000},"page":"152-161","source":"Crossref","is-referenced-by-count":36,"title":["Prevention of renal failure in Chinese patients with newly diagnosed type 2 diabetes: A cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"9","author":[{"given":"Bin","family":"Wu","sequence":"first","affiliation":[{"name":"Medical Decision and Economic Group Department of Pharmacy Ren Ji Hospital South Campus School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ren Ji Hospital School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houwen","family":"Lin","sequence":"additional","affiliation":[{"name":"Medical Decision and Economic Group Department of Pharmacy Ren Ji Hospital South Campus School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-9345","authenticated-orcid":false,"given":"Shan","family":"Mou","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ren Ji Hospital School of Medicine Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60439-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60033-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.146"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.3760\/cma.j.issn.0366-6999.20132906","article-title":"Chinese cohort study of chronic kidney disease: design and methods","volume":"127","author":"Gao B","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.883217"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.08.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-15"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-1296"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/08860228509088195"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-s249"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-1870"},{"key":"e_1_2_7_13_1","first-page":"661","article-title":"Screening for microalbuminuria to prevent nephropathy in patients with diabetes \u2013 A systematic review of the evidence","volume":"50","author":"Scheid DC","year":"2001","journal-title":"J Fam Pract"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01309.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7020.1595"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026139"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.2103"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.5372\/1905-7415.0803.301"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-131-9-199911020-00005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-2-200507190-00007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462309990584"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu312"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2013-003325"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000377"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60762-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0503-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp349"},{"key":"e_1_2_7_28_1","first-page":"423","article-title":"Chinese expert consensus for the microalbuminuria screening in hypertension and diabetes","volume":"20","author":"Hypertension Committee of CMDA, Chinese Endocrinologist Association (CEA), Hypertension CJo","year":"2012","journal-title":"Chinese J Hypertens"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X12455463"},{"key":"e_1_2_7_30_1","first-page":"7","article-title":"China guidelines for pharmacoeconomic evaluations","volume":"3","author":"Task Group of the Chinese Guidelines for Pharmacoeconomic Evaluations","year":"2011","journal-title":"China J Pharm Econom"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12195"},{"key":"e_1_2_7_32_1","unstructured":"List of Chinese administrative divisions by GDP per capita. Available from:http:\/\/en.wikipedia.org\/wiki\/List_of_Chinese_administrative_divisions_by_GDP_per_capita. Accessed October 28 2016."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2004.75003.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1050(200004)9:3<235::AID-HEC502>3.0.CO;2-O"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0951"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12379"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007994"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2011.01.001"},{"key":"e_1_2_7_39_1","first-page":"CD006257","article-title":"Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease","volume":"4","author":"Strippoli GF","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2325-z"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.4.874"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2398-8"},{"key":"e_1_2_7_43_1","unstructured":"Life tables for WHO Member States. Available from:http:\/\/www.who.int\/healthinfo\/statistics\/mortality_life_tables\/en\/. Accessed 2012 September 18."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61350-6"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2014.03.021"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-11-131"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-290"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02145.x"},{"key":"e_1_2_7_49_1","first-page":"911","article-title":"A comparative study on medical expenditure for diabetes mellitus and non\u2010diabetes mellitus in 9 provinces of China, between 2000 and 2009","volume":"34","author":"Wang HP","year":"2013","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_7_50_1","first-page":"66","article-title":"Analysis on budget impact of peritoneal dialysis for end\u2010stage renal disease","volume":"34","author":"Kun ZHAO","year":"2015","journal-title":"Chin Health Econom"},{"key":"e_1_2_7_51_1","unstructured":"WHO Collaborating Centre for Drug Statistics Methodology. Oslo Norway:2012. Guidelines for ATC classification and DDD assignment 2013. Available from:http:\/\/www.whocc.no\/filearchive\/publications\/1_2013guidelines.pdf. Accessed December 25 2015."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-15-165"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X15606903"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-015-0964-0"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.10.1051"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0281"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-13-390"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.04.025"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.06.022"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-3729.2001.00171.x"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdi.12653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.12653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T22:51:43Z","timestamp":1719096703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.12653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,25]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/jdi.12653"],"URL":"https:\/\/doi.org\/10.1111\/jdi.12653","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,25]]}}}