{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T02:19:29Z","timestamp":1780712369608,"version":"3.54.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>To investigate the relationship between pregnancy\u2010associated plasma protein A (<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A) and gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>), and to determine whether <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A has improved value for predicting <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> in a Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Clinical data for 599 <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> patients and 986 unaffected pregnant women undergoing both antenatal examinations and delivery were retrospectively analyzed. First\u2010trimester serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A levels were compared between the groups. Binary logistic regression analysis was used to explore the risk factors for <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>, and the area under the receiver operating characteristic curve was used to determine the value of <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A for predicting <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>\u2010affected and unaffected pregnant women were significantly different in terms of age (<jats:italic>P<\/jats:italic> &lt; 0.001), <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (<jats:italic>P<\/jats:italic> &lt; 0.001), family history of diabetes (<jats:italic>P<\/jats:italic> = 0.002), \u03b1\u2010thalassemia trait (<jats:italic>P<\/jats:italic> &lt; 0.01), parity (<jats:italic>P<\/jats:italic> &lt; 0.001), conception methods (<jats:italic>P<\/jats:italic> &lt; 0.001), gestational weeks at the time of labor (<jats:italic>P<\/jats:italic> &lt; 0.001) and corrected <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A multiples of the median values (<jats:italic>P<\/jats:italic> &lt; 0.001). Binary logistic regression analysis showed that <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A levels were negatively related to the subsequent development of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> (odds ratio 0.798, 95% confidence interval 0.647\u20130.984). The area under the receiver operating characteristic curve for maternal factors was 0.684 (95% CI: 0.657\u20130.711), and did not significantly differ from that for the combination of maternal factors and serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A levels, which was 0.686 (95% CI: 0.660\u20130.713; \u03c7<jats:sup>2<\/jats:sup> = 0.625, <jats:italic>P<\/jats:italic> = 0.429).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A was an independent factor for the development of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> in pregnant Chinese women. Serum\u2010<jats:styled-content style=\"fixed-case\">PAPP<\/jats:styled-content>\u2010A does not have improved value with respect to predicting <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> when combined with other maternal factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12672","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T06:04:44Z","timestamp":1491545084000},"page":"204-210","source":"Crossref","is-referenced-by-count":24,"title":["Gestational diabetes mellitus and first trimester pregnancy\u2010associated plasma protein A: A case\u2013control study in a Chinese population"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0982-647X","authenticated-orcid":false,"given":"Di","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Maternal and Child Healthcare Hospital of Shenzhen City Southern Medical University Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Chenhong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maternal and Child Healthcare Hospital of Shenzhen City Southern Medical University Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yanbin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maternal and Child Healthcare Hospital of Shenzhen City Southern Medical University Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Maternal and Child Healthcare Hospital of Shenzhen City Southern Medical University Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70144-5"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(14)70145-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(21)01073-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12396"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/565160"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.04.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.05.036"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2610"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182571669"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.04.023"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2733"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.07.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4103"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12270"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563213480493"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.684170"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03253.x"},{"key":"e_1_2_7_19_1","first-page":"30","article-title":"Association between pregnancy\u2010associated plasma protein\u2010A levels in the first trimester and gestational diabetes mellitus in Chinese women","volume":"22","author":"Cheuk QK","year":"2016","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_20_1","unstructured":"Definition diagnosis and classification of diabetes mellitus and its complications.Part 1: Diagnosis and classification of diabetes mellitus. 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