{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:41:59Z","timestamp":1787870519134,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Beijing Health Science Foundation","award":["2015-01"],"award-info":[{"award-number":["2015-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Patients with diabetes frequently develop orthostatic hypotension (<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>). The present study was designed to examine the relationship of blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) circadian rhythms and outcomes in diabetes with <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the present study, 173 inpatients with type 2 diabetes were enrolled. Patients were divided into an <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group and a non\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group according to the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> changes detected in the supine and standing position. Then, 24\u2010h ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was monitored. Patients were followed up for an average of 45\u00a0\u00b1\u00a010\u00a0months post\u2010discharge. Outcomes \u2013 death and major adverse cardiac and cerebrovascular events, including heart failure, myocardial infarction and stroke \u2013 were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 61 patients (35.26%) in the <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group and 112 patients (64.74%) in the non\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group. In the <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group, the night\u2010time systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and night\u2010time diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were higher, the blood <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> rhythms were predominantly of the riser type (67.21%). <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> was as an independent marker of riser type circadian rhythm (adjusted odds ratio 4.532, 95% confidence interval 2.579\u20137.966). In the <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group, the incidence rates of mortality, and major adverse cardiac and cerebrovascular events were increased significantly compared with those in the non\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> group (11.48 vs 2.68%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.014; 37.70 vs 8.93%, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients who had type 2 diabetes diagnosed with <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>, the <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> circadian rhythm usually showed riser patterns, and they had increased rates of mortality, and major adverse cardiac and cerebrovascular events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12691","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T20:26:51Z","timestamp":1494534411000},"page":"383-388","source":"Crossref","is-referenced-by-count":12,"title":["Blood pressure circadian rhythms and adverse outcomes in type 2 diabetes patients diagnosed with orthostatic hypotension"],"prefix":"10.1111","volume":"9","author":[{"given":"Jing","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Ping","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of 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