{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:28:43Z","timestamp":1778178523848,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T00:00:00Z","timestamp":1498435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is an autoimmune blistering skin disorder. Recently, <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> induced by dipeptidyl peptidase\u20104 (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104) inhibitors has been a concern. Although <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors are commonly used in the Asian population because of their safety and efficacy, <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors is sometimes seen in clinical settings. Here, we report five Japanese cases of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> associated with the agents. In the present cases, <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> occurred in older adults using four different <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors, which showed various clinical manifestations in terms of latency period for <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, sex, glycemic control and diabetes duration. Withdrawal of <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors was effective in improving <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, and achieved remission even in cases requiring oral steroid administration and intravenous immunoglobulin therapy. Clinicians should note the importance of early diagnosis of this clinical condition and initiate prompt withdrawal of <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104 inhibitors.<\/jats:p>","DOI":"10.1111\/jdi.12695","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T15:54:14Z","timestamp":1495122854000},"page":"445-447","source":"Crossref","is-referenced-by-count":40,"title":["Bullous pemphigoid associated with dipeptidyl peptidase\u20104 inhibitors: A report of five cases"],"prefix":"10.1111","volume":"9","author":[{"given":"Satoshi","family":"Yoshiji","sequence":"first","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin\u2010ichi","family":"Harashima","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riko","family":"Kashima","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-7687","authenticated-orcid":false,"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Rakuwakai Otowa Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-2593","authenticated-orcid":false,"given":"Nobuya","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14601"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2011.09.023"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(98)00008-X"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15111"},{"key":"e_1_2_5_7_1","unstructured":"World Health Organization Uppsala Monitoring Centre.The Use of the WHO\u2010UMC System for Standardized Case Causality Assessment [Monogram on the Internet]. 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