{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:53:13Z","timestamp":1784919193093,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010995","name":"Malaysian Society Nephrology","doi-asserted-by":"publisher","award":["RG\u20101\/2016"],"award-info":[{"award-number":["RG\u20101\/2016"]}],"id":[{"id":"10.13039\/100010995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25\u2010hydroxyvitamin D (25[OH]D) and glycemic control in non\u2010chronic kidney disease (CKD) patients with type 2 diabetes was reported. We aimed to examine this association among type 2 diabetes patients with CKD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 100 type 2 diabetes participants with stage 3\u20134 CKD were recruited. Blood for glycated hemoglobin (HbA<jats:sub>1c<\/jats:sub>), serum 25(OH)D, renal and lipid profiles were drawn at enrollment. Correlation and regression analyses were carried out to assess the relationship of serum 25(OH)D, HbA<jats:sub>1c<\/jats:sub> and other metabolic traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 30, 42, and 28% of participants were in CKD stage 3a, 3b and 4, respectively. The proportions of participants based on ethnicity were 51% Malay, 24% Chinese and 25% Indian. The mean (\u00b1SD) age and body mass index were 60.5 \u00b1 9.0 years and 28.3 \u00b1 5.9 kg\/m<jats:sup>2<\/jats:sup>, whereas mean HbA<jats:sub>1c<\/jats:sub> and serum 25(OH)D were 7.9 \u00b1 1.6% and 37.1 \u00b1 22.2 nmol\/L. HbA<jats:sub>1c<\/jats:sub> was negatively correlated with serum 25(OH)D (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120.314, <jats:italic>P<\/jats:italic> = 0.002), but positively correlated with body mass index (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = 0.272, <jats:italic>P<\/jats:italic> = 0.006) and serum low\u2010density lipoprotein cholesterol (<jats:italic>P<\/jats:italic> = 0.006). There was a significant negative correlation between serum 25(OH)D and total daily dose of insulin prescribed (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = \u22120.257, <jats:italic>P<\/jats:italic> = 0.042). Regression analyses showed that every 10\u2010nmol\/L decline in serum 25(OH)D was associated with a 0.2% increase in HbA<jats:sub>1c<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower serum 25(OH)D was associated with poorer glycemic control and higher insulin use among multi\u2010ethnic Asians with type 2 diabetes and stage 3\u20134 CKD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12696","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T15:53:10Z","timestamp":1495122790000},"page":"375-382","source":"Crossref","is-referenced-by-count":12,"title":["Association between serum 25\u2010hydroxyvitamin D and glycated hemoglobin levels in type 2 diabetes patients with chronic kidney disease"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-6924","authenticated-orcid":false,"given":"Lee Ling","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Endocrinology 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