{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:13:04Z","timestamp":1784070784230,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T00:00:00Z","timestamp":1502150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST103\u20102320\u2010B\u2010182\u2010026\u2010MY2"],"award-info":[{"award-number":["MOST103\u20102320\u2010B\u2010182\u2010026\u2010MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Diabetic nephropathy is one of the leading causes of end\u2010stage renal disease. Unfortunately, reliable surrogate markers for predicting the prognostic outcome of diabetic nephropathy are as yet absent. In order to find new markers in predicting the progression of diabetic nephropathy, we carried out a prospective study by investigating the correlation between serum metabolites and the annual change of estimated glomerular filtration rate (<jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>From September 2013 to September 2015, 52 diabetes patients at various stages of chronic kidney disease were enrolled. While serum levels of 175 metabolites were measured by Absolute<jats:styled-content style=\"fixed-case\">IDQ<\/jats:styled-content>\u2122 p180 kit, only those with a significant difference in advancing chronic kidney disease stages were selected. After then, serial renal function change of these patients was followed up for 12 months, the outcome of renal function with each selected metabolite was compared according to the occurrence of a rapid decline (sustained annual decrement rate \u22655%) of <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 26 metabolites were found to be significantly associated with the severity of chronic kidney disease. Tryptophan (Trp) showed a significant association with the event of rapid decline in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.036). Serum concentration of Trp &lt;44.20 \u03bcmol\/L showed the most valuable predictive value with 55.6% sensitivity and 87% specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A lower level of Trp, especially &lt;44.20 \u03bcmol\/L, was related to a rapid decline in <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>. Accordingly, Trp might be regarded as a potential prognostic marker for diabetic nephropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12707","type":"journal-article","created":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T14:04:35Z","timestamp":1498313075000},"page":"366-374","source":"Crossref","is-referenced-by-count":44,"title":["Tryptophan as a surrogate prognostic marker for diabetic nephropathy"],"prefix":"10.1111","volume":"9","author":[{"given":"Chien\u2010An","family":"Chou","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ni","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Chang Gung Memorial Hospital Linkou Branch Chang Gung University Taoyuan Taiwan"},{"name":"Department of Medical Biotechnology and Laboratory Science College of Medicine Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Tsun\u2010Yee","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology and Laboratory Science College of Medicine Chang Gung University Taoyuan Taiwan"},{"name":"Healthy Aging Research Center Chang Gung University Taoyuan Taiwan"},{"name":"Department of Pediatric Hematology Chang Gung Memorial Hospital Lin\u2010Kou Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2262-1775","authenticated-orcid":false,"given":"Szu\u2010Tah","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Chang Gung Memorial Hospital Chang Gung University Taoyuan 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