{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:52Z","timestamp":1787015512421,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007263","name":"Astellas Foundation for Research on Metabolic Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA; V\/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A total of 682 patients with type 2 diabetes (mean age 64 \u00b1 13 years; 41% women) were enrolled. VFA (cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and SFA (cm\n                      <jats:sup>2<\/jats:sup>\n                      ) were assessed by a dual bioelectrical impedance analyzer. The patients were divided into four groups according to the quartiles of the V\/S ratio. The study end\u2010point was the first occurrence or recurrence of CVD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median follow up of 2.5 years, 21 patients reached the end\u2010point. The number of patients who reached the end\u2010point was increased along with the increasing of the V\/S ratio quartiles. The V\/S ratio was significantly associated with incident or recurrent CVD (hazard ratio [HR] 1.82, 95% CI: 1.09\u20133.04,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.021) after adjusting for estimated glomerular filtration rate (HR 0.98, 95% CI: 0.96\u20131.00), brain\u2010type natriuretic peptide (HR 1.00, 95% CI: 1.00\u20131.01), use of antiplatelet agents (HR 4.26, 95% CI: 1.63\u201311.13), coefficient of variation of R\u2010R intervals (HR 0.85, 95% CI: 0.69\u20131.10) and glycated hemoglobin (HR 1.37, 95% CI: 1.05\u20131.79). The addition of the V\/S ratio to age, estimated glomerular filtration rate, brain\u2010type natriuretic peptide, antiplatelet agents and glycated hemoglobin significantly improved classification performance for CVD using net reclassification improvement (0.60, 95% CI: 0.21\u20131.00) and the integrated discrimination improvement (0.02, 95% CI: 0.00\u20130.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The V\/S ratio measured by dual bioelectrical impedance analyzer is an independent predictor of CVD in patients with type 2 diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.12713","type":"journal-article","created":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T10:07:33Z","timestamp":1499422053000},"page":"396-402","source":"Crossref","is-referenced-by-count":47,"title":["Ratio of visceral\u2010to\u2010subcutaneous fat area predicts cardiovascular events in patients with type 2 diabetes"],"prefix":"10.1111","volume":"9","author":[{"given":"Tatsuya","family":"Fukuda","sequence":"first","affiliation":[{"name":"Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-4342","authenticated-orcid":false,"given":"Ryotaro","family":"Bouchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takato","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Endocrinology and Metabolism Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo 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