{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:18:46Z","timestamp":1740158326583,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T00:00:00Z","timestamp":1505347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Aims\/Introduction<\/jats:title>Impaired glucose tolerance (IGT<\/jats:styled-content>) is a subtype of prediabetes, a condition having high risk for development to diabetes mellitus, but its pathophysiology is not fully understood. In the present study, we examined metabolic changes in IGT<\/jats:styled-content> by using two types (D\u2010<\/jats:italic>glucose [Glc] and partial hydrolysate of starch [PHS<\/jats:styled-content>]) of oral glucose tolerance tests (OGTT<\/jats:styled-content>s), with emphasis on serum incretins and metabolites.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>We carried out the two types of OGTT<\/jats:styled-content> (Glc\/OGTT<\/jats:styled-content> and PHS<\/jats:styled-content>\/OGTT<\/jats:styled-content>) in 99 young Japanese individuals who had tested either positive (GU<\/jats:styled-content>+<\/jats:sup>; n<\/jats:italic> = 48) or negative (GU<\/jats:styled-content>\u2212<\/jats:sup>; n<\/jats:italic> = 51) for glycosuria. After OGTT<\/jats:styled-content>, they were sub\u2010grouped into five categories: normal glucose tolerance (NGT<\/jats:styled-content>) in the GU<\/jats:styled-content>\u2212<\/jats:sup> group (GU<\/jats:styled-content>\u2212<\/jats:sup>\/NGT<\/jats:styled-content>; n<\/jats:italic> = 49), NGT<\/jats:styled-content> in the GU<\/jats:styled-content>+<\/jats:sup> group (GU<\/jats:styled-content>+<\/jats:sup>\/NGT<\/jats:styled-content>; n<\/jats:italic> = 28), IGT<\/jats:styled-content> (n<\/jats:italic> = 12), diabetes mellitus (n<\/jats:italic> = 1) and renal glycosuria (n<\/jats:italic> = 9). Serum incretin and metabolites of GU<\/jats:styled-content>\u2212<\/jats:sup>\/NGT<\/jats:styled-content> and IGT<\/jats:styled-content> were then measured.<\/jats:p><\/jats:sec>Results<\/jats:title>When the serum insulin level at each time\u2010point during PHS<\/jats:styled-content>\/OGTT<\/jats:styled-content> was expressed as its ratio relative to Glc\/OGTT<\/jats:styled-content>, it was increased time\u2010dependently in GU<\/jats:styled-content>\u2212<\/jats:sup>\/NGT<\/jats:styled-content>, but not in IGT<\/jats:styled-content>. Such an increase in the ratio was also detected of serum incretin levels in GU<\/jats:styled-content>\u2212<\/jats:sup>\/NGT<\/jats:styled-content>, but not in IGT<\/jats:styled-content>, suggesting a lack of deceleration of oligosaccharide absorption in IGT<\/jats:styled-content>. Metabolome analysis showed a difference in the serum levels of two metabolites of unknown function in mammals, methylcysteine and sedoheptulose 1,7\u2010bisphosphate, between GU<\/jats:styled-content>\u2212<\/jats:sup>\/NGT<\/jats:styled-content> and IGT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Comparison of PHS<\/jats:styled-content>\/OGTT<\/jats:styled-content> and Glc\/OGTT<\/jats:styled-content> showed that oligosaccharide absorption was accelerated in IGT<\/jats:styled-content>. Methylcysteine and sedoheptulose 1,7\u2010bisphosphate could be novel markers for dysregulated glucose metabolism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12719","type":"journal-article","created":{"date-parts":[[2017,8,2]],"date-time":"2017-08-02T10:04:16Z","timestamp":1501668256000},"page":"512-521","source":"Crossref","is-referenced-by-count":4,"title":["Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-1626","authenticated-orcid":false,"given":"Takashi","family":"Miki","sequence":"first","affiliation":[{"name":"Department of Medical Physiology Graduate School of Medicine Chiba University Chiba Japan"},{"name":"Division of Endocrinology and Metabolism Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akifumi","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Center for Preventive Medical Sciences Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Center for Preventive Medical Sciences Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Sawabe","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Chiba University Hospital Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Chiba University Hospital Chiba Japan"},{"name":"Safety and Health Organization Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Saito","sequence":"additional","affiliation":[{"name":"Safety and Health Organization Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetaka","family":"Yokoh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Chiba University Hospital Chiba Japan"},{"name":"Department of Clinical Cell Biology and Medicine Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Chiba University Hospital Chiba Japan"},{"name":"Department of Clinical Cell Biology and Medicine Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koutaro","family":"Yokote","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Chiba University Hospital Chiba Japan"},{"name":"Department of Clinical Cell Biology and Medicine Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kuzuya","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine School of Medicine Jichi Medical University Shimotsuke Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishi","family":"Miki","sequence":"additional","affiliation":[{"name":"Shikata Memorial Institute Miki Clinic Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Mori","sequence":"additional","affiliation":[{"name":"Center for Preventive Medical Sciences Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Nomura","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Chiba University Hospital Chiba Japan"},{"name":"Department of Molecular Diagnosis Graduate School of Medicine Chiba University Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60525-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0873"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.06.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-S005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2010.00074.x"},{"key":"e_1_2_7_7_1","first-page":"25","volume-title":"Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus: Abbreviated Report of a WHO Consultation","author":"World Health Organization","year":"2011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.14.2.96"},{"key":"e_1_2_7_9_1","first-page":"207","article-title":"A new carbohydrate solution, SDT\u201025 for testing oral glucose tolerance","volume":"11","author":"Ikeda Y","year":"1968","journal-title":"J Jpn Diabetes Soc"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.6.5.441"},{"key":"e_1_2_7_11_1","first-page":"131","article-title":"A case of impaired glucose tolerance showing blunt response to oral glucose tolerance test loading partially hydrolyzed starch, Trelan\u2010G\u00ae, but acute response to glucose","volume":"48","author":"Tokuyama Y","year":"2005","journal-title":"J Jpn Diabetes Soc"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00482-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2040-1124.2011.00163.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0555"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1951"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2008.50"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0754"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0570"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3656-y"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac900675k"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.024"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400362"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00159.2007"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(83)80232-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0246"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(79)90015-1"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.167304"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03291"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001831"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-12-208"},{"key":"e_1_2_7_33_1","first-page":"599","article-title":"The significance of sedoheptulose 1,7\u2010bisphosphate in the metabolism and regulation of the pentose pathway in liver","volume":"11","author":"Williams JF","year":"1985","journal-title":"Biochem Int"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000692"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010883"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-0598"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2071"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdi.12719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.12719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:28:35Z","timestamp":1695475715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.12719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,14]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/jdi.12719"],"URL":"https:\/\/doi.org\/10.1111\/jdi.12719","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"type":"print","value":"2040-1116"},{"type":"electronic","value":"2040-1124"}],"subject":[],"published":{"date-parts":[[2017,9,14]]}}}