{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:58:51Z","timestamp":1770285531942,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anagliptin (ANA) improves dyslipidemia in addition to blood glucose levels. However, there are no comparative studies on the effects of ANA and other dipeptidyl peptidase\u20104 inhibitors on serum lipid profile. We compared the effects of ANA on serum lipid profile with those of alogliptin (ALO) in type 2 diabetes mellitus outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study participants were 87 type 2 diabetes mellitus patients who had been treated with dipeptidyl peptidase\u20104 inhibitors for \u22658 weeks and had a low\u2010density lipoprotein cholesterol (LDL\u2010C) level of \u2265120 mg\/dL. Participants were switched to either 200 mg\/day ANA or 25 mg\/day ALO for 24 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in percentage change in LDL\u2010C level at 24 weeks between the ANA and ALO groups. Treatment with ANA for 12 weeks significantly decreased LDL\u2010C levels, one of the secondary end\u2010points. Treatment with ANA for 24 weeks significantly improved apolipoprotein B\u2010100 levels, and the percentage change in LDL\u2010C levels at 24 weeks correlated significantly with the percentage change in apolipoprotein B\u2010100 levels in the ANA group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The LDL\u2010C\u2010lowering effects of ANA and ALO at 24 weeks were almost similar in patients with type 2 diabetes mellitus. However, the results showed a tendency for a decrease in LDL\u2010C level at 24 weeks in the ANA group, and that such improvement was mediated, at least in part, through the suppression of apolipoprotein B\u2010100 synthesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12739","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T22:49:13Z","timestamp":1504046953000},"page":"360-365","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of effects of anagliptin and alogliptin on serum lipid profile in type 2 diabetes mellitus patients"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1768-3752","authenticated-orcid":false,"given":"Akira","family":"Kurozumi","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine School of Medicine University of Occupational and Environmental Health Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Okada","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine School of Medicine University of Occupational and Environmental Health Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Arao","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine School of Medicine University of Occupational and Environmental Health Japan"},{"name":"Department of Internal Medicine Japan Labour Health and Welfare Organization Kyushu Rosai Hospital Moji Medical Center Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisaku","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuya","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine School of Medicine University of Occupational and Environmental Health 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