{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:50:07Z","timestamp":1790175007513,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T00:00:00Z","timestamp":1509062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012627","name":"Japan Diabetes Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012627","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We compared the efficacy of insulin detemir and biphasic insulin aspart\u201030 given in the morning as an add\u2010on to oral hypoglycemic agents in type 2 diabetes patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The present study enrolled 30 patients with poorly controlled type 2 diabetes (8% \u2264 glycated hemoglobin &lt; 11%) being treated with oral hypoglycemic agent mono\u2010 or combination therapy with biguanides, sulfonylureas or thiazolidinediones. The patients were randomly assigned to insulin detemir (group D) or insulin aspart\u201030 (group A) given in the morning as add\u2010on to oral hypoglycemic agents. After adjusting their insulin doses, the patients that underwent continuous glucose monitoring during a 3\u2010day hospitalization and with day 2 continuous glucose monitoring data were subjected to analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in patient background, baseline glycated hemoglobin levels and insulin doses during continuous glucose monitoring between the two groups. The percent coefficient of variation of 24\u2010h glucose levels was significantly lower in group A (20.4 \u00b1 7.6) than in group D (27.1 \u00b1 6.5; <jats:italic>P<\/jats:italic> = 0.015). Similarly, mean amplitude of glycemic excursions was significantly smaller in group A (80 \u00b1 32) than in group D (102 \u00b1 14; <jats:italic>P<\/jats:italic> = 0.021). Postprandial glucose excursions were significantly smaller after breakfast in group A (65 \u00b1 31 mg\/dL) than in group D (106 \u00b1 32 mg\/dL; <jats:italic>P<\/jats:italic> = 0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As once\u2010daily insulin injection therapy given before breakfast in type 2 diabetes patients, the biphasic insulin analog might represent a better insulin option in significantly lowering the percent coefficient of variation and mean amplitude of glycemic excursions than the long\u2010acting insulin preparation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12747","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T14:11:12Z","timestamp":1505743872000},"page":"573-578","source":"Crossref","is-referenced-by-count":4,"title":["Biphasic insulin aspart\u201030 reduces glycemic variability to a greater degree than insulin detemir: A randomized controlled trial of once\u2010daily insulin regimens using continuous glucose monitoring"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9304-8307","authenticated-orcid":false,"given":"Daisuke","family":"Tsujino","sequence":"first","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimei","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Onda","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Ando","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Utsunomiya","sequence":"additional","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Internal Medicine Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.11.1249"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036361"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2441"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3460-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075392"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.01014.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1612"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007990903354674"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2005.00563.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.04.012"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12097"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700524"}],"container-title":["Journal 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