{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:47:41Z","timestamp":1784054861855,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Grant\u2010in\u2010Aids for Scientific Research"],"award-info":[{"award-number":["Grant\u2010in\u2010Aids for Scientific Research"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The glucose\u2010lowering effects of the glucagon\u2010like peptide\u20101 receptor agonist, liraglutide, have been shown to rely on remaining \u03b2\u2010cell function. However, the possible associations of remaining \u03b2\u2010cell function with the glucose\u2010lowering effects of liraglutide in combination with basal insulin remain unknown and warrant investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a single\u2010center, retrospective, observational study carried out in a private hospital in Osaka, Japan. Type 2 diabetes patients who received a prescription change from insulin therapy, both multiple\u2010dose insulin and basal insulin\u2010supported oral therapy, to liraglutide and basal insulin combination and continued the therapy for 54 weeks without additional oral antidiabetic drugs or bolus insulin were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 72 participants who received a prescription change from multiple\u2010dose insulin and basal insulin\u2010supported oral therapy to liraglutide and basal insulin combination, 57 continued the therapy for 54 weeks. Of those who continued the therapy without receiving additional oral antidiabetic drugs or bolus insulin, seven participants achieved glycated hemoglobin &lt; 7.0% at 54 weeks, but 30 participants did not. The participants who achieved glycated hemoglobin &lt; 7.0% at 54 weeks had a significantly higher C\u2010peptide immunoreactivity index, a \u03b2\u2010cell function\u2010related index frequently used in Japanese clinical settings. The receiver operating curve analysis showed that the C\u2010peptide immunoreactivity index cut\u2010off value for the achievement of glycated hemoglobin &lt;7.0% at 54 weeks is 1.103.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current findings show that the glucose\u2010lowering effects of liraglutide rely on remaining \u03b2\u2010cell function, even when used with basal insulin; and suggest that liraglutide and basal insulin combination might require additional bolus insulin to fully compensate insulin insufficiency in individuals with reduced \u03b2\u2010cell function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12773","type":"journal-article","created":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T07:52:56Z","timestamp":1509954776000},"page":"822-830","source":"Crossref","is-referenced-by-count":28,"title":["Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes patients: The association between remaining \u03b2\u2010cell function and the achievement of the glycated hemoglobin target 1 year after initiation"],"prefix":"10.1111","volume":"9","author":[{"given":"Ryota","family":"Usui","sequence":"first","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism Kansai Electric Power Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Sakuramachi","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Endocrinology and Metabolism Kansai Electric Power Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Seino","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology and Diabetes Metabolic Medicine Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Division of Biostatistics 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