{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:07:46Z","timestamp":1782122866045,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T00:00:00Z","timestamp":1517270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81354867"],"award-info":[{"award-number":["81354867"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Atorvastatin is usually used to decrease the amount of fatty substances in individuals with type 2 diabetes mellitus. However, it can cause side\u2010effects, such as breakdown of skeletal muscle tissue. The present study focused on the effects of atorvastatin on autophagy of the skeletal muscles in diabetic rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Diabetes in rats in the diabetic (D) and atorvastatin (T) groups was induced using streptozotocin (65 mg\/kg, intraperitoneal injection). Next, rats in the T group were treated with atorvastatin (10 mg\/kg\/day, intragastric administration), whereas rats in the control and D groups were given water. Additionally, the rats in T and D groups were fed a high\u2010fat and high\u2010sugar diet for 10 weeks. Subsequently, the histopathological changes, and expression levels of microtubule\u2010associated protein 1 light chain 3 (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3)\u2010I\/\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and p62 in the skeletal muscle specimens in the three groups were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rats in the T group had reduced lipid droplets, cholesterol and low\u2010density lipoprotein (<jats:italic>P<\/jats:italic> &lt; 0.05) levels than those in the D group. Disordered atrophic myocytes, incrassated vascular walls and decreased cross\u2010sectional area of type I fibers were found using hematoxylin\u2013eosin and adenosine triphosphatase staining in the D and T groups. The messenger ribonucleic acid and protein levels of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3\u2010I ratio were increased in the T group compared with those in the other groups (<jats:italic>P<\/jats:italic> &lt; 0.05), whereas the protein level of p62 showed the opposite trend.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Atorvastatin enhanced the autophagy level of skeletal muscles to decrease lipid deposition, which possibly exacerbated myopathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12789","type":"journal-article","created":{"date-parts":[[2017,12,16]],"date-time":"2017-12-16T21:49:55Z","timestamp":1513460995000},"page":"753-761","source":"Crossref","is-referenced-by-count":11,"title":["Effects of atorvastatin on autophagy in skeletal muscles of diabetic rats"],"prefix":"10.1111","volume":"9","author":[{"given":"Bingquan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Zhongda Hospital Institute of Diabetes School of Medicine Southeast University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of 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