{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:34:57Z","timestamp":1790037297547,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T00:00:00Z","timestamp":1520899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>A decrease in the size of the pancreas is observed in islet autoantibody\u2010positive non\u2010diabetic donors and acute\u2010onset type\u00a01 diabetes irrespective of the diabetes duration. Little is known, however, about the relationship between the size of the pancreas and type\u00a01 diabetes subtypes, including fulminant type\u00a01 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We examined the pancreatic volume (<jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content>) in 44 adult patients with type\u00a01 diabetes (16 acute\u2010onset type\u00a01 diabetes, 18 slowly progressive type\u00a01 diabetes and 10 fulminant type\u00a01 diabetes) and 39 age\u2010 and body mass index\u2010matched non\u2010diabetic controls. <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> was measured by computed tomography. The ability to secrete insulin was assessed by stimulated C\u2010peptide after intravenous glucagon administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> was significantly correlated with bodyweight in both control participants and type\u00a01 diabetes patients. The <jats:styled-content style=\"fixed-case\">PV<\/jats:styled-content> index (<jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> PV<\/jats:styled-content>\/bodyweight) was decreased by 39% in type\u00a01 diabetes compared with that in controls. <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> was significantly decreased in acute\u2010onset type\u00a01 diabetes patients and slowly progressive type\u00a01 diabetes patients (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), but not in fulminant type\u00a01 diabetes patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.10), compared with control participants. In cases patients with recent\u2010onset type\u00a01 diabetes (0\u20137\u00a0days post\u2010diagnosis), <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> was significantly decreased in acute\u2010onset type\u00a01 diabetes patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0005), but not in fulminant type\u00a01 diabetes patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a07, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.44), compared with controls. <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> showed no correlations with the diabetes duration, C\u2010peptide levels, glycated hemoglobin, glutamic acid decarboxylase autoantibody levels, serum amylase or daily total insulin dose in type\u00a01 diabetes subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present results show that patients with acute\u2010onset type\u00a01 diabetes and slowly progressive type\u00a01 diabetes have small pancreases irrespective of the diabetes\u00a0duration or C\u2010peptide levels. In contrast to earlier findings on acute\u2010onset type\u00a01 diabetes, we found no reduction of <jats:styled-content style=\"fixed-case\">PVI<\/jats:styled-content> at the onset of fulminant type\u00a01 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12816","type":"journal-article","created":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T10:36:35Z","timestamp":1518258995000},"page":"1091-1099","source":"Crossref","is-referenced-by-count":25,"title":["Analysis of pancreatic volume in acute\u2010onset, slowly\u2010progressive and fulminant type\u00a01 diabetes in a Japanese population"],"prefix":"10.1111","volume":"9","author":[{"given":"Hiroto","family":"Sasamori","sequence":"first","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Department of Medicine Showa University School of Medicine Tokyo Japan"},{"name":"Gaienhigashi Clinic Tokyo 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