{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:35:07Z","timestamp":1784709307549,"version":"3.55.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,29]],"date-time":"2018-04-29T00:00:00Z","timestamp":1524960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>) is a risk for adverse perinatal outcomes, and patients with a history of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> have an increased risk of impaired glucose tolerance (<jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>). Here, we carried out two non\u2010interventional and retrospective studies of <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> patients in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the first study, we enrolled 529 <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> patients and assessed predictors of the need for insulin therapy. In the second study, we enrolled 185 patients from the first study, and assessed predictors of postpartum <jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first study, gestational weeks at <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> diagnosis and history of pregnancy were significantly lower, and pregestational body mass index, family history of diabetes mellitus, 1\u2010 and 2\u2010h glucose levels in a 75\u2010g oral glucose tolerance test (<jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>), the number of abnormal values in a 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>, and glycated hemoglobin were significantly higher in participants receiving insulin therapy. In the second study, 1\u2010 and 2\u2010h glucose levels in a 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>, the number of abnormal values in a 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content>, glycated hemoglobin, and ketone bodies in a urine test were significantly higher in participants with <jats:styled-content style=\"fixed-case\">OGT<\/jats:styled-content>. Logistic regression analysis showed that gestational weeks at <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> diagnosis, 1\u2010h glucose levels in a 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> and glycated hemoglobin were significant predictors of the need for insulin therapy, and 1\u2010h glucose levels in a 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> at diagnosis and ketone bodies in a urine test were significant predictors for postpartum <jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Antepartum 1\u2010h glucose levels in a 75\u2010g <jats:styled-content style=\"fixed-case\">OGTT<\/jats:styled-content> was a predictor of the need for insulin therapy in pregnancy and postpartum <jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12848","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T22:29:15Z","timestamp":1523053755000},"page":"1370-1377","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["One\u2010hour oral glucose tolerance test plasma glucose at gestational diabetes diagnosis is a common predictor of the need for insulin therapy in pregnancy and postpartum impaired glucose tolerance"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2528-8963","authenticated-orcid":false,"given":"Takeshi","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology National Hospital Organization Kumamoto Medical Center Kumamoto 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