{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:25:16Z","timestamp":1781360716027,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T00:00:00Z","timestamp":1532476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) might be drug\u2010induced. The present study evaluated the relationship between <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> and dipeptidyl peptidase\u20104 inhibitors (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4Is).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We recruited patients diagnosed with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> at Ogaki Municipal Hospital from 1 December 2009 through 31 December 2017. We retrospectively collected data from medical records and divided patients into two groups based on whether they received <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4Is. Additionally, we determined the incidence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in patients who were first prescribed <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4Is at our hospital during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 168 patients diagnosed with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, 133 (79.1%) were positive for anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a antibody. A total of 32 (19.0%) patients had been prescribed a <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4I, 21 of whom (65.6%) were positive for anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a antibody; this rate was lower than that in patients not receiving a <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4I (82.3%; <jats:italic>P<\/jats:italic> = 0.0360). A total of 16 patients with type 2 diabetes mellitus had not been prescribed a <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4I; only one (6.3%) was positive for anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a antibody (<jats:italic>P<\/jats:italic> = 0.0339). During the study period, 9,304 patients were prescribed <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4Is, eight of whom developed <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>; six (75.0%) had non\u2010inflammatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, and five of the six (83.3%) were negative for anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a antibody.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The positive rate of anti\u2010<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>180<jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>16a antibody was lower in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4I than without <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4I, regardless of type 2 diabetes mellitus. The antibody titer was low in both the overall and type 2 diabetes mellitus populations. The prevalence of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in 9,304 patients receiving <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4Is was 0.0859%, which is higher than that in the general population. As <jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>4Is are common diabetes treatments, we must be aware of the risk of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12877","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T19:22:06Z","timestamp":1529436126000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Dipeptidyl peptidase\u20104 inhibitors\u2010associated bullous pemphigoid: A retrospective study of 168 pemphigoid and 9,304 diabetes mellitus patients"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1027-5038","authenticated-orcid":false,"given":"Yohei","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Department of Diabetology and Nephrology Ogaki Municipal Hospital Ogaki 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