{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:38:58Z","timestamp":1776112738259,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Steroid\u2010induced hyperglycemia (<jats:styled-content style=\"fixed-case\">SIHG<\/jats:styled-content>) has shown to independently increase the risk for mortality in patients with acute graft\u2010versus\u2010host disease, and it is still unclear whether <jats:styled-content style=\"fixed-case\">SIHG<\/jats:styled-content> might be a modifiable risk factor. Therefore, a feasibility trial was carried out aiming to evaluate the performance of a standardized decision support system (GlucoTab [<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>]) for insulin therapy in patients with <jats:styled-content style=\"fixed-case\">SIHG<\/jats:styled-content>. A total of 10 hyperglycemic acute graft\u2010versus\u2010host disease patients were included and treated either with <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> or standard of care during hospitalization. Follow\u2010up duration was 6\u00a0months. Comparing the <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> versus standard of care group, 364 versus 1,020 glucose readings were available during a median of 41\u00a0days (interquartile range [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>] 22\u201389) and 101\u00a0days (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 55\u2013147) of hospitalization. The median overall glucose levels were 151\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> (123\u2013192) versus 162\u00a0mg\/<jats:styled-content style=\"fixed-case\">dL<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 138\u2013193) for <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> and standard of care, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001); hypoglycemia rates were comparably low. Treatment of <jats:styled-content style=\"fixed-case\">SIHG<\/jats:styled-content> with an algorithm\u2010based system for subcutaneous insulin was feasible and safe.<\/jats:p>","DOI":"10.1111\/jdi.12919","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T13:28:47Z","timestamp":1535203727000},"page":"339-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility and safety of using an automated decision support system for insulin therapy in\u00a0the treatment of steroid\u2010induced hyperglycemia in patients with acute graft\u2010versus\u2010host disease: A randomized trial"],"prefix":"10.1111","volume":"10","author":[{"given":"Felix","family":"Aberer","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia K","family":"Mader","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Holzgruber","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Trummer","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Schwetz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlene","family":"Pandis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N","family":"Pferschy","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildegard","family":"Greinix","sequence":"additional","affiliation":[{"name":"Division of Hematology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert J","family":"Tripolt","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R","family":"Pieber","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetology Medical University of Graz Graz Austria"},{"name":"Center for Biomarker Research in Medicine (CBmed) Graz 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