{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:16:53Z","timestamp":1786652213996,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471019\/H0712"],"award-info":[{"award-number":["81471019\/H0712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700708\/H0712"],"award-info":[{"award-number":["81700708\/H0712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Aims\/Introduction<\/jats:title>Duodenal\u2010jejunal bypass (DJB<\/jats:styled-content>) surgery has been reported to effectively relieve diabetic cardiomyopathy (DCM<\/jats:styled-content>). However, the specific mechanisms remain largely unknown. The present study was designed to determine the alterations of myocardial glucose uptake (MGU<\/jats:styled-content>) after DJB<\/jats:styled-content> and their effects on DCM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Duodenal\u2010jejunal bypass and sham surgeries were carried out in diabetic rats induced by a high\u2010fat diet and a low dose of streptozotocin, with chow\u2010diet fed rats as controls. Bodyweight, food intake, glucose homeostasis and lipid profiles were measured at indicated time\u2010points. Cardiac function was evaluated by transthoracic echocardiography and hemodynamic measurement. Cardiac remodeling was assessed by a series of morphometric analyses along with transmission electron microscopy. Positron\u2010emission tomography with fluorine\u201018 labeled fluorodeoxyglucose was carried out to evaluate the MGU <\/jats:styled-content>in vivo<\/jats:italic>. Furthermore, myocardial glucose transporters (GLUT; GLUT<\/jats:styled-content>1 and GLUT<\/jats:styled-content>4), myocardial insulin signaling and GLUT<\/jats:styled-content>\u20104 translocation\u2010related proteins were investigated to elucidate the underlying mechanisms.<\/jats:p><\/jats:sec>Results<\/jats:title>The DJB<\/jats:styled-content> group showed restored systolic and diastolic cardiac function, along with significant remission in cardiac hypertrophy, cardiac fibrosis, lipid deposit and ultrastructural disorder independent of weight loss compared with the sham group. Furthermore, the DJB<\/jats:styled-content> group showed upregulated myocardial insulin signaling, hyperphosphorylation of AKT<\/jats:styled-content> substrate of 160 kD<\/jats:styled-content>a (AS<\/jats:styled-content>160) and TBC<\/jats:styled-content>1D1, along with preserved soluble N\u2010ethylmaleimide\u2010sensitive factor attachment protein receptor<\/jats:styled-content> proteins, facilitating the GLUT<\/jats:styled-content>\u20104 translocation to the myocardial cell surface and restoration of MGU<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The present findings provide evidence that restoration of MGU<\/jats:styled-content> is implicated in the alleviation of DCM<\/jats:styled-content> after DJB<\/jats:styled-content> through facilitating GLUT<\/jats:styled-content>\u20104 translocation, suggesting a potential choice for treatment of human DCM<\/jats:styled-content> if properly implemented.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12948","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T09:53:43Z","timestamp":1538819623000},"page":"626-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Restoration of myocardial glucose uptake with facilitated myocardial glucose transporter 4 translocation contributes to alleviation of diabetic cardiomyopathy in rats after duodenal\u2010jejunal bypass"],"prefix":"10.1111","volume":"10","author":[{"given":"Xin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General Surgery Qilu Hospital of Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Qilu Hospital of Shandong University Jinan 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