{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:02:59Z","timestamp":1749535379786,"version":"3.37.3"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008644","name":"Japan Diabetes Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008644","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>Aims\/Introduction<\/jats:title>To evaluate the contribution of pancreatic \u03b1\u2010cell function to the dawn phenomenon, insulin sensitivity, hepatic glucose uptake and glycemic variability in patients with type\u00a01 diabetes.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>In 40 patients with type\u00a01 diabetes, arginine stimulation tests were carried out, and the area under the curve (AUC) of glucagon was measured using radioimmunoassays (AUC<\/jats:styled-content>glc<\/jats:sub>RIA<\/jats:sub><\/jats:styled-content>) and enzyme\u2010linked immunosorbent assays (AUC<\/jats:styled-content>glc<\/jats:sub>ELISA<\/jats:sub><\/jats:styled-content>). The ratio of the insulin dose delivered by an artificial pancreas to maintain euglycemia between 04.00 and 08.00\u00a0hours or between 00.00 and 04.00\u00a0hours was measured as the dawn index. The glucose infusion rate and hepatic glucose uptake<\/jats:styled-content> were measured using hyperinsulinemic euglycemic clamp and clamp oral glucose loading tests. Glycemic variability in 96\u00a0h was measured by continuous glucose monitoring.<\/jats:p><\/jats:sec>Results<\/jats:title>The median dawn index (1.7, interquartile range 1.0\u20132.8) was not correlated with AUC<\/jats:styled-content>glc<\/jats:sub>RIA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.03, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.39) or AUC<\/jats:styled-content>glc<\/jats:sub>ELISA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.04, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.32). The median glucose infusion rate<\/jats:styled-content> (7.3\u00a0mg\/kg\/min, interquartile range 6.4\u20139.2\u00a0mg\/kg\/min) was significantly correlated with AUC<\/jats:styled-content>glc<\/jats:sub>RIA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.20, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02) and AUC<\/jats:styled-content>glc<\/jats:sub>ELISA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.21, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.02). The median hepatic glucose uptake<\/jats:styled-content> (65.3%, interquartile range 40.0\u201387.3%) was not correlated with AUC<\/jats:styled-content>glc<\/jats:sub>RIA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.07, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.26) or AUC<\/jats:styled-content>glc<\/jats:sub>ELISA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.26, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.79). The standard deviation of glucose levels measured by continuous glucose monitoring<\/jats:styled-content> was significantly correlated with AUC<\/jats:styled-content>glc<\/jats:sub>RIA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.11, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.049), but not with AUC<\/jats:styled-content>glc<\/jats:sub>ELISA<\/jats:sub><\/jats:styled-content> (R<\/jats:italic>2<\/jats:sup>\u00a0=\u00a00.01, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.75).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Pancreatic \u03b1\u2010cell function contributed to insulin sensitivity in patients with type\u00a01 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12949","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T10:05:04Z","timestamp":1538820304000},"page":"690-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Contribution of pancreatic \u03b1\u2010cell function to insulin sensitivity and glycemic variability in patients with type\u00a01 diabetes"],"prefix":"10.1111","volume":"10","author":[{"given":"Nobuyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Metabolism Center Hospital National Center for Global Health and Medicine Tokyo Japan"},{"name":"Department of Molecular Diabetology Graduate School of Medicine The University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7727-6310","authenticated-orcid":false,"given":"Daisuke","family":"Chujo","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Metabolism Center Hospital National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kajio","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Metabolism Center Hospital National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohjiro","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, and Metabolism Center Hospital National Center for Global Health and Medicine Tokyo Japan"},{"name":"Department of Molecular Diabetology Graduate School of Medicine The University of Tokyo Tokyo Japan"},{"name":"Diabetes Research Center Research Institute National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.20.7.1183"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006639107"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization: World Health Organization International Diabetes Federation editors.Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. 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