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Therefore, it is important to identify and reduce the risk factors of diabetic foot. Cigarette smoking has been reported to be associated with diabetes and its macrovascular complications, but the relationship between smoking and diabetic foot ulcers is still unclear. In the present review, we summarize the effects of cigarette smoking on diabetic foot ulcers with respect to peripheral neuropathy, vascular alterations and wound healing. One underlying mechanism of these impacts might be the smoking\u2010induced oxidative stress inside the cells. At the end of this review, the current mainstream therapies for smoking cessation are also outlined. We believe that it is urgent for all diabetic patients to quit smoking so as to reduce their chances of developing foot ulcers and to improve the prognosis of diabetic foot ulcers.<\/jats:p>","DOI":"10.1111\/jdi.12952","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T02:19:55Z","timestamp":1539137995000},"page":"202-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Review of the role of cigarette smoking in diabetic foot"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6540-5701","authenticated-orcid":false,"given":"Nan","family":"Xia","sequence":"first","affiliation":[{"name":"Diabetes &amp; Wound Care Center Mingci Cardiovascular Hospital Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Morteza","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Research Center \u2013 EMRC Vali\u2010Asr. 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