{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:23:22Z","timestamp":1754108602432,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anti\u2010glutamic acid decarboxylase antibody (<jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content>) is an important islet cell\u2010associated autoantibody for the diagnosis of autoimmune type\u00a01 diabetes mellitus. In Japan, the <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> assay kit was recently changed from radioimmunoassay (<jats:styled-content style=\"fixed-case\">RIA<\/jats:styled-content>) to enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>). Thereafter, a mismatched measurement between the two tests became apparent in clinical situations. The present study aimed to clarify the actual extent of mismatch between the two measurements on a larger\u2010scale real\u2010world clinical practice. In this cross\u2010sectional non\u2010local\/non\u2010hospital\u2010based study, we collected anonymized data on <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> levels of 598 participants, who were simultaneously measured with <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RIA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> enzyme\u2010linked immunosorbent assay tests. We found that 34% of the <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RIA<\/jats:styled-content>\u2010positive participants showed negative results in the <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content> enzyme\u2010linked immunosorbent assay test; the mismatch was predominantly observed in participants with relatively low <jats:styled-content style=\"fixed-case\">GADA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RIA<\/jats:styled-content> levels (&lt;32\u00a0U\/<jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>). This considerable mismatch might lead to physicians\u2019 confusion in diagnosing type\u00a01 diabetes mellitus.<\/jats:p>","DOI":"10.1111\/jdi.12955","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T10:23:04Z","timestamp":1539253384000},"page":"685-689","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Actual condition survey regarding mismatch of measurements between radioimmunoassay and enzyme\u2010linked immunosorbent assay tests for anti\u2010glutamic acid decarboxylase antibody in real\u2010world clinical practice"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-6751","authenticated-orcid":false,"given":"Yoichi","family":"Oikawa","sequence":"first","affiliation":[{"name":"Committee for Optimization of Medical Equipment and Pharmaceuticals Japan Association for Diabetes Education and Care Tokyo Japan"},{"name":"Department of Endocrinology and Diabetes School of Medicine Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Kondo","sequence":"additional","affiliation":[{"name":"Committee for Optimization of Medical Equipment and Pharmaceuticals Japan Association for Diabetes Education and Care Tokyo Japan"},{"name":"Third Department of Internal Medicine Division of Diabetes, Endocrinology and Metabolism Kyorin University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes School of Medicine Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-7989","authenticated-orcid":false,"given":"Yutaka","family":"Seino","sequence":"additional","affiliation":[{"name":"Committee for Optimization of Medical 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