{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:19:05Z","timestamp":1740158345229,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Relationships between cardiometabolic risk and glycemia have rarely been studied in people under clinical evaluation and treatment for cardiometabolic risk and with prediabetes. We investigated relationships between glycemia and cardiometabolic risk factors in clinic participants with prediabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a cross\u2010sectional analysis of data collected at a center in Thailand. Clinic attendees were at high risk of diabetes or cardiovascular disease, with hemoglobin A1c (HbA1c) 39\u2013&lt;48\u00a0mmol\/mol or fasting plasma glucose (<jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content>) 5.6\u2013&lt;7.0\u00a0mmol\/L. The relationships between glycemia and cardiometabolic risk factors were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 357 participants, two or more insulin resistance\u2010related metabolic disturbances were present in 84%; 61% took a statin and 75% an antihypertensive agent. Independently of age, sex, adiposity, medication use, possible non\u2010alcoholic fatty liver disease and sex\u2013glycemia interaction, neither <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content> nor HbA1c were associated with variation in any other cardiometabolic risk factors. High\u2010density lipoprotein cholesterol decreased with HbA1c in women (female\u2013HbA1c interaction, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) but, unexpectedly, increased with <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content> in men (male\u2013<jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content> interaction, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, in Thai people treated for high cardiometabolic risk and with prediabetes defined by <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content> and\/or HbA1c, neither <jats:styled-content style=\"fixed-case\">FPG<\/jats:styled-content> nor HbA1c were associated with other cardiometabolic risk factors. However, according to sex, high\u2010density lipoprotein cholesterol showed the expected relationship with glycemia in women, but the reverse in men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12967","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T08:33:22Z","timestamp":1541147602000},"page":"771-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiometabolic risk factors in Thai individuals with prediabetes treated in a high\u2010risk, prevention clinic: Unexpected relationship between high\u2010density lipoprotein cholesterol and glycemia in men"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-7117","authenticated-orcid":false,"given":"Weerachai","family":"Srivanichakorn","sequence":"first","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Medicine Department of Medicine Imperial College London London 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Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phunchai","family":"Charatcharoenwitthaya","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornpoj","family":"Pramyothin","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tullaya","family":"Sitasuwan","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukana","family":"Preechasuk","sequence":"additional","affiliation":[{"name":"Siriraj Diabetes Center Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Elkeles","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Medicine Department of Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K George MM","family":"Alberti","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Medicine Department of Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Desmond G","family":"Johnston","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Medicine Department of Medicine Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick S","family":"Oliver","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology and Metabolic Medicine Department of Medicine Imperial College London London 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