{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:55:45Z","timestamp":1787162145587,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18dk0207025"],"award-info":[{"award-number":["JP18dk0207025"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18ek0210080"],"award-info":[{"award-number":["JP18ek0210080"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18ek0210082"],"award-info":[{"award-number":["JP18ek0210082"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18ek0210083"],"award-info":[{"award-number":["JP18ek0210083"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18fk0108075"],"award-info":[{"award-number":["JP18fk0108075"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18gm0610007"],"award-info":[{"award-number":["JP18gm0610007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18km0405202"],"award-info":[{"award-number":["JP18km0405202"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>The present study aimed to examine cross\u2010sectional associations between objectively measured sedentary time and the prevalence of diabetes mellitus in a general Japanese population, and to elucidate possible mediating roles of diet, obesity and insulin resistance in this relationship.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A total of 1,758 community\u2010dwelling individuals aged 40\u201379\u00a0years wore an accelerometer for \u22657\u00a0days and underwent a comprehensive health examination in 2012. Diabetes mellitus was diagnosed by a 75\u2010g oral glucose tolerance test. The associations of sedentary time with the presence of diabetes mellitus and the levels of the homeostasis model assessment of insulin resistance were estimated by logistic and linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After adjustment for demographic and lifestyle factors including moderate\u2010to\u2010vigorous physical activity, participants who spent \u226510\u00a0h in sedentary time had a significantly higher odds ratio of the presence of diabetes than those who spent &lt;6\u00a0h in sedentary time (odds ratio 1.84, 95% confidence interval 1.02\u20133.31). This significant association remained after adjusting for overall and central obesity (as measured by body mass index and waist circumference), but weakened after adjusting for dietary energy intake or homeostasis model assessment of insulin resistance. Sedentary time was positively associated with homeostasis model assessment of insulin resistance levels among non\u2010diabetic participants after adjusted for obesity or energy intake (\n                      <jats:italic>P<\/jats:italic>\n                      for trend &lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Longer sedentary time was associated with a higher prevalence of diabetes mellitus in a general Japanese population. Insulin resistance appeared to be mainly involved in this association. These results highlight the importance of public health strategies targeting reductions in sedentary time for the primary prevention of diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.12968","type":"journal-article","created":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T04:29:07Z","timestamp":1541132947000},"page":"809-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Objectively measured sedentary time and diabetes mellitus in a general Japanese population: The Hisayama Study"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1011-9879","authenticated-orcid":false,"given":"Takanori","family":"Honda","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiro","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-9116","authenticated-orcid":false,"given":"Naoko","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Department of Psychosomatic Medicine Kyushu University Hospital Fukuoka City Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Ohara","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzo","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Center for Health Science and Counseling Kyushu University Kasuga City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"},{"name":"Center for Cohort Studies Graduate School of Medical Sciences Kyushu University Fukuoka City Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61031-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3181e373a2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1651"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.812"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.161.12.1542"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.14.1785"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2009.00047.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150095"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.726"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.3.612"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1773"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.11.020"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12544"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2015-095648"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12136"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002424"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12250"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2010.01.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510005441"},{"key":"e_1_2_7_21_1","unstructured":"National Institute of Cancer: SAS Programs for Analyzing NHANES 2003\u20102004 Accelerometer Data. Available fromhttps:\/\/epi.grants.cancer.gov\/nhanes_pam\/Accessed November 30 2017."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm390"},{"key":"e_1_2_7_23_1","volume-title":"Global Recommendations on Physical Activity for Health","author":"World Health Organization","year":"2010"},{"key":"e_1_2_7_24_1","first-page":"100","article-title":"A study on convenient dietary assessment [Japanese]","volume":"37","author":"Shirota T","year":"1990","journal-title":"Jpn J Public Health"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0226"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3861-8"},{"key":"e_1_2_7_28_1","first-page":"634","article-title":"Sedentary behavior and prevalent diabetes in Non\u2010Latino Whites, Non\u2010Latino Blacks and Latinos: findings from the National Health Interview Survey","volume":"37","author":"Larsen BA","year":"2015","journal-title":"J Pub Health"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4193-z"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-0153(03)00053-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2015.04.013"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016938"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq451"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1895"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020503"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.153288"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00698.2011"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12876"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/31.1.163"}],"container-title":["Journal of Diabetes Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdi.12968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.12968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdi.12968","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdi.12968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T15:56:07Z","timestamp":1694361367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdi.12968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,29]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/jdi.12968"],"URL":"https:\/\/doi.org\/10.1111\/jdi.12968","archive":["Portico"],"relation":{},"ISSN":["2040-1116","2040-1124"],"issn-type":[{"value":"2040-1116","type":"print"},{"value":"2040-1124","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,29]]},"assertion":[{"value":"2018-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}