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In GIP<jats:sup>gfp\/gfp<\/jats:sup> mice, weight gain, subcutaneous and visceral fat mass were reduced, and glucose intolerance was improved compared with wild\u2010type mice with the same magnitude of insulin responses. Cancellous bone mineral density and bone cortical thickness were reduced in GIP<jats:sup>gfp\/gfp<\/jats:sup> mice compared with wild\u2010type mice. In GIP<jats:sup>gfp\/+<\/jats:sup> mice, weight gain, glucose intolerance and cancellous bone mineral density were not different from that of wild\u2010type mice. These results indicate that the total elimination of GIP ameliorates weight gain and adiposity in ovariectomized mice, but it enhances osteopenia, particularly in cancellous bone by partly suppressing bone formation.<\/jats:p>","DOI":"10.1111\/jdi.12978","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T14:12:36Z","timestamp":1542636756000},"page":"909-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glucose\u2010dependent insulinotropic polypeptide deficiency reduced fat accumulation and insulin resistance, but deteriorated bone loss in ovariectomized mice"],"prefix":"10.1111","volume":"10","author":[{"given":"Satoko","family":"Shimazu\u2010Kuwahara","sequence":"first","affiliation":[{"name":"Preemptive Medicine and Lifestyle\u2010related Disease Research Center Kyoto University Hospital Kyoto Japan"},{"name":"Department of Diabetes, Endocrinology and Nutrition Graduate 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