{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:03:50Z","timestamp":1790795030832,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007830","name":"Kitasato University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease is frequently associated with type\u00a02 diabetes, and constitutes an important risk factor for the development of hepatic fibrosis and hepatocellular carcinoma. Because there remains no effective drug therapy for <jats:styled-content style=\"fixed-case\">non\u2010alcoholic fatty liver disease<\/jats:styled-content> associated with type\u00a02 diabetes, we evaluated the efficacy of sodium\u2013glucose cotransporter\u00a02 inhibitor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>In the present pilot, prospective, non\u2010randomized, open\u2010label, single\u2010arm study, we evaluated the effect of 100\u00a0mg canagliflozin administered once daily for 12\u00a0months on serological markers, body composition measured by bioelectrical impedance analysis method and hepatic fat fraction measured by magnetic resonance imaging in type\u00a02 diabetes patients with <jats:styled-content style=\"fixed-case\">non\u2010alcoholic fatty liver disease<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Canagliflozin significantly reduced body and fat mass, and induced a slight decrease in lean body or muscle mass that did not reach significance at 6 and 12\u00a0months. Reductions in fat mass in each body segment (trunk, arms and legs) were evident, whereas those in lean body mass were not. <jats:styled-content style=\"fixed-case\">The hepatic fat fraction<\/jats:styled-content> was reduced from a baseline of 17.6\u00a0\u00b1\u00a07.5% to 12.0\u00a0\u00b1\u00a04.6% after 6\u00a0months and 12.1\u00a0\u00b1\u00a06.1% after 12\u00a0months (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0005 and <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.005), whereas serum liver enzymes and type<jats:styled-content style=\"fixed-case\">\u00a0IV<\/jats:styled-content> collagen concentrations improved. From a mean baseline hemoglobin A1c of 8.7\u00a0\u00b1\u00a01.4%, canagliflozin significantly reduced hemoglobin A1c after 6 and 12\u00a0months to 7.3\u00a0\u00b1\u00a00.6% and 7.7\u00a0\u00b1\u00a00.7% (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0005 and <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Canagliflozin reduced body mass, fat mass and hepatic fat content without significantly reducing muscle mass.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12980","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T13:30:51Z","timestamp":1542807051000},"page":"1004-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Effects of canagliflozin on body composition and hepatic fat content in type\u00a02 diabetes patients with non\u2010alcoholic fatty liver disease"],"prefix":"10.1111","volume":"10","author":[{"given":"Mitsuko","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9946-1004","authenticated-orcid":false,"given":"Akinori","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Kitasato University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riina","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes 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