{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:28:47Z","timestamp":1787671727397,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/04831\u20101"],"award-info":[{"award-number":["2012\/04831\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims\/Introduction<\/jats:title>\n                    <jats:p>Epigenetics participate in the pathogenesis of metabolic memory, a situation in which hyperglycemia exerts prolonged deleterious effects even after its normalization. We tested the hypothesis that genetic variants in an epigenetic gene could predispose to diabetes complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      We assessed the frequency of five single\u2010nucleotide polymorphisms in the gene encoding\n                      <jats:styled-content style=\"fixed-case\">deoxyribonucleic acid<\/jats:styled-content>\n                      methytransferase\u00a01 (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>\n                        1;\n                      <\/jats:italic>\n                      rs8112895, rs7254567, rs11085721, rs17291414 and rs10854076), and their associations with diabetic kidney disease, retinopathy, distal polyneuropathy and autonomic cardiovascular neuropathy in 359 individuals with long\u2010term type\u00a01 diabetes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      None of the single\u2010nucleotide polymorphisms studied was significantly associated with the presence of chronic complications in the overall population. However, after sex stratification, the minor allele C of rs11085721 conferred risk for\n                      <jats:styled-content style=\"fixed-case\">cardiovascular neuropathy<\/jats:styled-content>\n                      in women after adjustment for confounding variables (odds ratio 2.32; 95% confidence interval 1.26\u20134.33;\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The fact that heterozygous mutations in\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">DNMT<\/jats:styled-content>\n                        1\n                      <\/jats:italic>\n                      are associated with hereditary sensory autonomic neuropathy provides plausibility to the present finding. If confirmed in independent samples, it suggests that genetic variants in epigenetic genes might predispose to more or fewer epigenetic changes in the face of similar metabolic derangements triggered by hyperglycemia, constituting the \u201cgenetics of epigenetics\u201d for microvascular diabetes complications.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdi.12988","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T01:39:05Z","timestamp":1544578745000},"page":"985-989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic variants in\n                    <i>\n                      <scp>DNMT<\/scp>\n                      1\n                    <\/i>\n                    and the risk of cardiac autonomic neuropathy in women with type\u00a01 diabetes"],"prefix":"10.1111","volume":"10","author":[{"given":"Daniele Pereira","family":"Santos\u2010Bezerra","sequence":"first","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon Nina","family":"Admoni","sequence":"additional","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"},{"name":"Division of Endocrinology Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana Cristina","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biomedical Sciences University of Sao Paulo University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Souza","family":"Pelaes","sequence":"additional","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Vesoni","family":"Perez","sequence":"additional","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleide Guimar\u00e3es","family":"Machado","sequence":"additional","affiliation":[{"name":"Division of Oftalmology Clinical Hospital Medical School University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatriz","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Candida","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Joao","family":"Pavin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP) Campinas Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Silva","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Clinical Hospital Medical School University of Sao Paulo Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubiratan Fabres","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Institute of Biomedical Sciences University of Sao Paulo University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-4446","authenticated-orcid":false,"given":"Maria Lucia","family":"Correa\u2010Giannella","sequence":"additional","affiliation":[{"name":"Laboratory of Carbohydrates and Radioimuneassays (LIM\u201018) Clinical Hospital Medical School University of Sao Paulo Universidade 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