{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:51:16Z","timestamp":1784181076162,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW105\u2010TDU\u2010B\u2010211\u2010133016"],"award-info":[{"award-number":["MOHW105\u2010TDU\u2010B\u2010211\u2010133016"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,7]]},"abstract":"Abstract<\/jats:title>Aims\/Introduction<\/jats:title>Helicobacter pylori<\/jats:italic> infection is associated with insulin resistance and glycemia in non\u2010diabetes. However, the relationship between H.\u00a0pylori<\/jats:italic> infection and glycemia in diabetes remains inconclusive. Therefore, we explored the effect of H.\u00a0pylori<\/jats:italic> infection status and its eradication on glycemic control and antidiabetic therapy in type\u00a02 diabetes patients.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>A total of 549 diabetes patients were recruited for sequential two\u2010step approach (immunoglobulin\u00a0G [IgG] serology followed by 13<\/jats:sup>C\u2010urea breath test [UBT]<\/jats:styled-content>) to discriminate \u201cactive\u201d (IgG+ and UBT<\/jats:styled-content>+) from \u201cnon\u2010active\u201d (UBT<\/jats:styled-content>\u2212 or IgG\u2212) H.\u00a0pylori<\/jats:italic> infection, and \u201cpast\u201d (IgG+ but UBT<\/jats:styled-content>\u2212) from \u201cnever\/remote\u201d (IgG\u2212) infection. The differences in hemoglobin A1c (A1C) and antidiabetic regimens between groups were compared. In the \u201cactive\u201d infection group, the differences in A1C changes between participants with and without 10\u2010day eradication therapy were compared after 3\u00a0months.<\/jats:p><\/jats:sec>Results<\/jats:title>Despite no between\u2010group difference in A1C, the \u201cactive\u201d infection group (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>208) had significantly more prescriptions of oral antidiabetic drug classes (2.1\u00a0\u00b1\u00a01.1 vs 1.8\u00a0\u00b1\u00a01.1, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.004) and higher percentages of sulfonylurea use (67.3% vs 50.4%, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001) than the \u201cnon\u2010active\u201d infection group (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>341). There were no differences in A1C and oral antidiabetic drug<\/jats:styled-content> classes between \u201cpast\u201d (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>111) and \u201cnever\/remote\u201d infection groups (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>230). Compared with the non\u2010eradication group (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>99), the eradication group (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>98) had significant within\u2010group (\u22120.17\u00a0\u00b1\u00a00.80%, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.036) and between\u2010group (\u22120.23\u00a0\u00b1\u00a00.10%, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.024) improvements in A1C.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Diabetes patients with active H.\u00a0pylori<\/jats:italic> infection need higher glycemic treatment intensity to achieve comparable glycemia. Furthermore, H.\u00a0pylori<\/jats:italic> eradication decreases A1C, and thus improves glycemic control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.12991","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T05:43:04Z","timestamp":1545025384000},"page":"1092-1101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Helicobacter pylori<\/i> eradication improves glycemic control in type\u00a02 diabetes patients with asymptomatic active Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"10","author":[{"given":"Kai\u2010Pi","family":"Cheng","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Jong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Chang","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Institute of Basic Medical Sciences College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching\u2010Han","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Tai","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Division of Gastroenterology Department of Internal Medicine National Cheng Kung University Hospital College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Hui","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Nursing Shu\u2010Zen Junior College of Medicine and Management Kaohsiung 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