{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T22:52:57Z","timestamp":1771368777774,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>It is suspected that <jats:italic>Helicobacter pylori<\/jats:italic> is associated with extradigestive diseases including diabetes. So far, a number of studies have examined the association between <jats:italic>H.\u00a0pylori<\/jats:italic> and diabetes, and the results were conflicting. The aim of the present study was to examine the association between <jats:italic>H.\u00a0pylori<\/jats:italic> infection, eradication and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The present cross\u2010sectional study was carried out using data from annual health checkups carried out at the Toranomon Hospital Health Management Center. The status of <jats:italic>H.\u00a0pylori<\/jats:italic> infection, determined by serum antibodies and history of eradication, was categorized into three groups as \u201cnever,\u201d \u201ccurrent\u201d and \u201cpast.\u201d The association between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and diabetes was examined using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 21,634 participants, 6,530 (30.2%) had a current or past history of <jats:italic>H.\u00a0pylori<\/jats:italic> infection, and 1,184 (5.5%) were identified as having diabetes. Multivariate adjusted odds ratios for diabetes compared with the \u201cnever\u201d group were 1.36 (95% <jats:styled-content style=\"fixed-case\">confidence interval<\/jats:styled-content> 1.10\u20131.67) for the \u201ccurrent\u201d group and 0.92 (95% <jats:styled-content style=\"fixed-case\">confidence interval<\/jats:styled-content> 0.79\u20131.07) for the \u201cpast\u201d group. The association between <jats:italic>H.\u00a0pylori<\/jats:italic> infection and diabetes was also observed among participants without a history of eradication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found that current <jats:italic>H.\u00a0pylori<\/jats:italic> infection was associated with an increased risk of diabetes, and the increased risk was not observed among participants after eradication. The results were concordant with the hypothesis that <jats:italic>H.\u00a0pylori<\/jats:italic> infection increases the risk of diabetes. Further studies are necessary to validate the present results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13011","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T08:40:08Z","timestamp":1548060008000},"page":"1341-1346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Association between <i>Helicobacter pylori<\/i> infection, eradication and diabetes mellitus"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-0673","authenticated-orcid":false,"given":"Masayuki","family":"Kato","sequence":"first","affiliation":[{"name":"Health Management Center Toranomon Hospital Tokyo Japan"},{"name":"Okinaka Memorial Institute for Medical Research Toranomon Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Toda","sequence":"additional","affiliation":[{"name":"Health Management Center Toranomon Hospital 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