{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:12:09Z","timestamp":1785841929804,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05251"],"award-info":[{"award-number":["16H05251"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["28\u2010Shi\u20101206"],"award-info":[{"award-number":["28\u2010Shi\u20101206"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>We examined a prospective association between serum creatinine levels and diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The present study included 31,343 male workers without diabetes, and aged between 20 and 64\u00a0years at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either glycated hemoglobin levels \u22656.5%, random glucose levels \u2265200\u00a0mg\/dL, fasting glucose levels \u2265126\u00a0mg\/dL or receiving antidiabetic treatment. Cox proportional hazards regression analysis was carried out to estimate the hazard ratio (HR) and 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median observation of 7.7\u00a0years, 2,509 participants developed diabetes. After adjusting for age, smoking, body mass index, hypertension and dyslipidemia, lower cumulative average serum creatinine levels were related to a greater diabetes risk: HRs were 1.56 (95% CI 1.35\u20131.82), 1.22 (1.09\u20131.35) and 1.06 (0.96\u20131.17) for the participants with serum creatinine &lt;0.70, 0.70\u20130.79 and 0.80\u20130.89\u00a0mg\/dL, respectively, compared with those with 0.90\u20131.20\u00a0mg\/dL (<jats:italic>P<\/jats:italic> for trend &lt;0.001). The serum creatinine\u2010diabetes association was more pronounced among older adults (serum creatinine &lt;0.70 vs 0.90\u20131.20\u00a0mg\/dL, HR 1.66, 95% CI 1.37\u20132.00) than younger adults (HR 1.32, 95% CI 1.02\u20131.71; <jats:italic>P<\/jats:italic> for interaction by age group\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Low serum creatinine is associated with an increased risk of diabetes. Screening serum creatinine levels can be used to identify those who are at high risk of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13024","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T09:47:50Z","timestamp":1550051270000},"page":"1209-1214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Low serum creatinine and risk of diabetes: The Japan Epidemiology Collaboration on Occupational Health Study"],"prefix":"10.1111","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8558-2895","authenticated-orcid":false,"given":"Huanhuan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Prevention National Center for Global Health and Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Hitachi, Ltd. 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Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Yamaha Corporation Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Nippon Steel and Sumitomo Metal Corporation Kimitsu Works Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Furukawa Electric Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kochi","sequence":"additional","affiliation":[{"name":"Furukawa Electric Co., Ltd. Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Mizue Medical Clinic Keihin Occupational Health Center Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Murakami","sequence":"additional","affiliation":[{"name":"Mizue Medical Clinic Keihin Occupational Health Center Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tomita","sequence":"additional","affiliation":[{"name":"Mitsubishi Plastics, Inc. 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