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However, the precise mechanisms of action of these drugs are not well understood. In the present study, we evaluated the effect of treatment with tofogliflozin for 6\u00a0months on cardiac and vascular endothelial function in 26 patients with type\u00a02 diabetes and heart diseases. Tofogliflozin treatment significantly decreased left ventricular end\u2010diastolic dimensions and significantly increased flow\u2010mediated vasodilation. Although <jats:italic>E\/e<\/jats:italic>\u2032 did not significantly change after treatment, the decrease observed in the <jats:italic>E\/e<\/jats:italic>\u2032 ratio was significantly correlated with the increase in acetoacetic acid and 3\u2010hydroxybutyrate levels. These results suggest that sodium\u2013glucose cotransporter\u00a02 inhibitor might improve left ventricular dilatation and vascular endothelial function in patients with type\u00a02 diabetes. Furthermore, it is suggested that the elevation of ketone bodies induced by sodium\u2013glucose cotransporter\u00a02 inhibitors might contribute to a protective effect in left ventricular diastolic dysfunction.<\/jats:p>","DOI":"10.1111\/jdi.13122","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T15:04:28Z","timestamp":1564499068000},"page":"400-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effect of tofogliflozin on cardiac and vascular endothelial function in patients with type\u00a02 diabetes and heart diseases: A pilot study"],"prefix":"10.1111","volume":"11","author":[{"given":"Mayu","family":"Tochiya","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism National Cerebral and Cardiovascular Center Suita Osaka 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