{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:22:50Z","timestamp":1788992570047,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T00:00:00Z","timestamp":1572739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H05251"],"award-info":[{"award-number":["16H05251"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012319","name":"National Center for Global Health and Medicine","doi-asserted-by":"publisher","award":["28\u2010Shi\u20101206"],"award-info":[{"award-number":["28\u2010Shi\u20101206"]}],"id":[{"id":"10.13039\/100012319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>We examined the association between hemoglobin A1c (HbA1c) and anemia, which was categorized into three groups according to mean corpuscular volume (MCV), as well as the association between hemoglobin in the non\u2010anemic range and HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We used the 2016 health checkup data from 36,422 workers without diabetes. Anemic people were divided into three groups based on MCV: &lt;80, 80\u201390 and &gt;90\u00a0fL. Non\u2010anemic people were divided into four groups based on their hemoglobin levels. We carried out multiple linear regression models to estimate the means and 95% confidence intervals (CIs) of HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For men, 0.2% had anemia with MCV\u00a0&lt;80\u00a0fL, 0.5% had anemia with MCV 80\u201390\u00a0fL, 0.9% had anemia with MCV\u00a0&gt;90\u00a0fL and 98.4% had no anemia. For women, the corresponding values were 6.1, 6.4, 2.8 and 84.7%, respectively. The adjusted mean HbA1c (%) values for men with anemia with MCV\u00a0&lt;80, 80\u201390 and &gt;90\u00a0fL were 5.67 (95% CI 5.60\u20135.74), 5.58 (95% CI 5.54\u20135.62) and 5.41 (95% CI 5.37\u20135.44), respectively. Among men without anemia, HbA1c (%) increased from 5.36 (95% CI 5.34\u20135.39) in those with hemoglobin \u226517.5\u00a0mg\/dL to 5.45 (95% CI 5.45\u20135.46) in those with hemoglobin 13.0 to &lt;14.5\u00a0mg\/dL (<jats:italic>P<\/jats:italic> for trend &lt;0.001). The HbA1c values were higher in men with anemia with MCV\u00a0&lt;80\u00a0fL or MCV 80\u201390\u00a0fL, but lower in men with MCV &gt;90\u00a0fL, compared with non\u2010anemic men with hemoglobin 13.0 to &lt;14.5\u00a0mg\/dL (All <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Similar findings were observed in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed elevated HbA1c among anemic people with MCV\u00a0&lt;80\u00a0fL or MCV 80\u201390\u00a0fL, and decreased HbA1c among anemic people with MCV\u00a0&gt;90\u00a0fL, suggesting that different types of anemia might influence HbA1c differently. In addition, non\u2010anemic people with lower hemoglobin levels had higher HbA1c levels, suggesting that hemoglobin levels are in need of consideration when interpreting HbA1c values among non\u2010anemic people.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13159","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T16:34:02Z","timestamp":1570898042000},"page":"719-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Associations of anemia and hemoglobin with hemoglobin A1c among non\u2010diabetic workers in Japan"],"prefix":"10.1111","volume":"11","author":[{"given":"Nobuaki","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Health Design Inc. 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