{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:58:04Z","timestamp":1791907084243,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601403"],"award-info":[{"award-number":["81601403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>A retrospective study was carried out to investigate the clinical characteristics and associated factors for invasive fungal disease in patients with type\u00a02 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Demographic and clinical data were recorded. Associated factors were analyzed by logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Invasive fungal disease was diagnosed in 120 patients with type\u00a02 diabetes mellitus (prevalence, 0.4%). Yeast infection (56\/120, 46.7%), including candidiasis (31\/56, 55.4%) and cryptococcosis (25\/56, 44.6%), was the most common. The urinary tract was mainly involved in candidiasis (12\/31, 38.7%). More than half of the cryptococcosis (16\/25, 64.0%) presented as pneumonia. Mold infection accounted for 40.8% of the cases, and predominantly involved the lung (34\/49, 69.4%). A total of 15 (12.5%) patients had mixed fungal infection. <jats:italic>Candida albicans<\/jats:italic> (24\/111, 21.6%), <jats:italic>Cryptococcus neoformans<\/jats:italic> (19\/111, 17.1%) and <jats:italic>Aspergillus fumigatus<\/jats:italic> (14\/111, 12.6%) were the leading agents. Co\u2010infection occurred in 58 (48.3%) patients, mainly presenting as pneumonia caused by Gram\u2010negative bacteria. The inpatient mortality rate of invasive fungal disease was 23.3% (28\/120). Glycated hemoglobin levels were higher in non\u2010survivors than survivors (8.8\u00a0\u00b1\u00a02.5 vs 7.7\u00a0\u00b1\u00a02.1%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.02). Anemia (adjusted odds ratio, 3.50, 95% confidence interval 1.95\u20136.27, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001), hypoalbuminemia (adjusted odds ratio, 5.42, 95% confidence interval 3.14\u20139.36, <jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>0.001) and elevated serum creatinine (adjusted odds ratio, 2.08, 95% confidence interval 1.07\u20134.04, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.03) were associated with invasive fungal disease in type\u00a02 diabetes mellitus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Invasive fungal disease is a life\u2010threatening complication in type\u00a02 diabetes mellitus patients. <jats:italic>C.\u00a0a albicans<\/jats:italic>, <jats:italic>C.\u00a0neoformans<\/jats:italic>, and <jats:italic>A.\u00a0fumigatus<\/jats:italic> are the leading agents. Prolonged hyperglycemia results in unfavorable outcomes. Correction of anemia and hypoalbuminemia might improve prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13183","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T06:29:42Z","timestamp":1574490582000},"page":"731-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Opportunistic invasive fungal disease in patients with type\u00a02 diabetes mellitus from Southern China: Clinical features and associated factors"],"prefix":"10.1111","volume":"11","author":[{"given":"Minxi","family":"Lao","sequence":"first","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Geriatrics The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou 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