{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T08:11:48Z","timestamp":1785831108685,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>The renal threshold for glucose (RTg) corresponds to a blood glucose level of ~180\u00a0mg\/dL; however, in hospitals, patients are often encountered who are hyperglycemic, but urine glucose test strip\u2010negative, who remain negative for urine glucose even at blood glucose concentrations &gt;180\u00a0mg\/dL, implying a high RTg value. In this study, we aimed to identify factors determining high RTg in Japanese patients with type\u00a02 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We estimated RTg (eRTg)\u00a0using urinalysis data from 67 type\u00a02 diabetes mellitus patients for whom the glucose infusion rate (GIR) was determined by hyperinsulinemic\u2010euglycemic clamp. After allocating patients to two groups according to their baseline eRTg (&lt;180\u00a0mg\/dL or \u2265180\u00a0mg\/dL), we identified the factors affecting eRTg using simple and multiple linear regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GIR, glycated hemoglobin (HbA1c), insulin use and dyslipidemia differed significantly between the groups. In simple regression analysis, GIR, HbA1c, body muscle\u2010to\u2010fat ratio and insulin use were significantly correlated with eRTg; and in multiple regression analysis, GIR and HbA1c remained independent negative and positive determinants, respectively, with the contribution of GIR being substantial. In receiver operating characteristic curve analysis, when GIR\u00a0&lt;5.7 was used as the insulin resistance threshold, the cut\u2010off value of eRTg was 189\u00a0mg\/dL (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001). Furthermore, in receiver operating characteristic analysis using eRTg\u00a0\u2265189\u00a0mg\/dL, the cut\u2010off value for HbA1c was 8.0% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High eRTg is associated with low GIR and high HbA1c, with GIR making a substantial contribution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13191","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T17:07:00Z","timestamp":1574788020000},"page":"617-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Elevation of the renal threshold for glucose is associated with insulin resistance and higher glycated hemoglobin levels"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7786-4646","authenticated-orcid":false,"given":"Kunio","family":"Hieshima","sequence":"first","affiliation":[{"name":"Diabetes Care Center Jinnouchi Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seigo","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Diabetes Care Center Jinnouchi Hospital Kumamoto Japan"},{"name":"Cardiovascular Division Diabetes Care Center Jinnouchi Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Diabetes Care Center Jinnouchi Hospital Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Kurinami","sequence":"additional","affiliation":[{"name":"Diabetes Care Center Jinnouchi Hospital Kumamoto 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