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The correlation between CgA and glycated hemoglobin was significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), but weak (<jats:italic>R\u00a0<\/jats:italic>=\u00a0+0.32). A slight, but steady elevation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0410) in CgA level was observed to co\u2010vary with the duration of type\u00a01 diabetes. Enterochromaffin\u2010like cell hyperplasia and autoimmune gastritis was significantly more frequent (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0087 for both) in the high CgA group. Detailed analyses on gastric tissue samples confirmed a progression of enterochromaffin\u2010like cell hyperplasia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0192) accompanied by CgA elevation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0316).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The early detection and follow up of the later progression of enterochromaffin\u2010like cell hyperplasia and autoimmune gastritis into gastric neuroendocrine tumors, which have ~100\u2010fold greater incidence in type\u00a01 diabetes patients, can be achieved by assessment of CgA levels. Therefore, the use of CgA could be considered as a novel auxiliary biomarker in the care of these type\u00a01 diabetes complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13203","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T20:10:26Z","timestamp":1577563826000},"page":"865-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum chromogranin\u00a0A level continuously rises with the progression of type\u00a01 diabetes, and indicates the presence of both enterochromaffin\u2010like cell hyperplasia and autoimmune gastritis"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5990-4889","authenticated-orcid":false,"given":"Zoltan","family":"Herold","sequence":"first","affiliation":[{"name":"2nd Department of Internal Medicine Semmelweis University Budapest 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