{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:28:07Z","timestamp":1771230487099,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We present the first case of simultaneous development of Graves\u2019 disease and type\u00a01 diabetes during anti\u2010programmed cell death\u00a01 therapy. A 48\u2010year\u2010old man with parotid gland adenocarcinoma and lung metastasis had received five courses of nivolumab. Fourteen\u00a0days after administration of the sixth course, his casual plasma glucose and hemoglobin A1c levels were 379\u00a0mg\/dL and 7.2%, respectively. Furthermore, thyrotoxicosis was detected with a blood test. Serum total ketone body and thyroid\u2010stimulating hormone receptor antibody levels increased, and serum C\u2010peptide level decreased to 0.01\u00a0ng\/mL thereafter. Thus, we concluded that he simultaneously developed anti\u2010programmed cell death\u00a01 therapy\u2010associated type\u00a01 diabetes and Graves\u2019 disease. Among Japanese patients with autoimmune polyglandular syndrome type\u00a0III, the frequency of human leukocyte antigen\u2010DRB1*04:05 is higher in those with both type\u00a01 diabetes and Graves\u2019 disease. Our case had human leukocyte antigen\u2010DRB1*04:05, which might be associated with the simultaneous development of the two diseases.<\/jats:p>","DOI":"10.1111\/jdi.13212","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T14:14:13Z","timestamp":1578752053000},"page":"1006-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Simultaneous development of Graves\u2019 disease and type\u00a01 diabetes during anti\u2010programmed cell death\u20101 therapy: A case report"],"prefix":"10.1111","volume":"11","author":[{"given":"Susumu","family":"Kurihara","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Saitama Medical University International Medical Center Saitama Japan"},{"name":"Department of Endocrinology and Diabetes School of Medicine Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1524-6751","authenticated-orcid":false,"given":"Yoichi","family":"Oikawa","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes School of Medicine Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Saitama Medical University International Medical Center Saitama Japan"},{"name":"Department of Endocrinology and Diabetes School of Medicine Saitama Medical University Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Satomura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes School of Medicine Saitama Medical University Saitama 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