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We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV\u00a0:\u00a0ICV (an indicator of global brain atrophy) and HV\u00a0:\u00a0ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean values of the TBV\u00a0:\u00a0ICV and HV\u00a0:\u00a0ICV ratios decreased significantly with elevating serum GA levels and GA\u00a0:\u00a0HbA<jats:sub>1c<\/jats:sub> ratio levels (all <jats:italic>P<\/jats:italic> for trend\u00a0&lt;\u00a00.05), but not with higher HbA<jats:sub>1c<\/jats:sub> levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA\u00a0:\u00a0HbA<jats:sub>1c<\/jats:sub> ratio levels, but not HbA<jats:sub>1c<\/jats:sub>, were closely associated with lower mean values of the TBV\u00a0:\u00a0ICV and HV\u00a0:\u00a0ICV ratios, irrespective of the presence or absence of diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggests that higher serum GA and higher GA\u00a0:\u00a0HbA<jats:sub>1c<\/jats:sub> ratio are significantly associated with global brain and hippocampal atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13220","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T17:37:30Z","timestamp":1580405850000},"page":"971-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elevated serum glycated albumin and glycated albumin\u00a0:\u00a0hemoglobin A<sub>1c<\/sub> ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7426-4290","authenticated-orcid":false,"given":"Tomoyuki","family":"Ohara","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Graduate School of Medical Sciences Kyushu University Fukuoka Japan"},{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka 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