{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:51:29Z","timestamp":1776289889494,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["KAKENHI 23680069, 26282197, 17K19929"],"award-info":[{"award-number":["KAKENHI 23680069, 26282197, 17K19929"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Individuals with a monophasic glucose response curve (GRC) during a 75\u2010g oral glucose tolerance test have a higher risk for type\u00a02 diabetes than those with a biphasic GRC. However, no studies have addressed the association between GRC type and insulin clearance. Thus, we studied 49 healthy non\u2010obese Japanese men. We divided study participants into the monophasic or biphasic group based on the shape of their GRC. We evaluated tissue\u2010specific insulin sensitivity and insulin clearance using a two\u2010step hyperinsulinemic\u2010euglycemic clamp. The monophasic group had more visceral fat, lower insulin clearance and lower muscle insulin sensitivity than the biphasic group, whereas liver and adipose tissue insulin sensitivity, and insulin secretion were comparable. In conclusion, healthy non\u2010obese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity.<\/jats:p>","DOI":"10.1111\/jdi.13227","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T08:20:47Z","timestamp":1580890847000},"page":"874-877","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non\u2010obese men"],"prefix":"10.1111","volume":"11","author":[{"given":"Hideyoshi","family":"Kaga","sequence":"first","affiliation":[{"name":"Department of Metabolism &amp; Endocrinology Juntendo University Graduate School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7821","authenticated-orcid":false,"given":"Yoshifumi","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Metabolism &amp; 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