{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:28:32Z","timestamp":1788316112562,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type\u00a0A insulin resistance (IR) syndrome is a severe IR form caused by insulin receptor (<jats:italic>INSR<\/jats:italic>) gene defects. Antidiabetic drugs, including high\u2010dose insulin and insulin\u2010sensitizing agents, often fail to control associated hyperglycemia. Therapy with recombinant human insulin\u2010like growth factor\u00a01 can be more effective, but it is expensive. We report a case of type\u00a0A IR syndrome with an in\u2010frame <jats:italic>INSR<\/jats:italic> heterozygous deletion (\u0394Leu999) that was treated with a combination of conventional therapy and ipragliflozin, a sodium\u2013glucose cotransporter\u00a02 inhibitor. Treatment reduced hemoglobin A1c levels (10.0\u20137.5%) and induced weight loss (54.4\u201352.0\u00a0kg) within 2\u00a0months, and the effects were sustained for &gt;3\u00a0years. Sodium\u2013glucose cotransporter\u00a02 inhibitors might be useful to normalize blood glucose in type\u00a0A IR syndrome by reducing bodyweight and ameliorating glucotoxicity.<\/jats:p>","DOI":"10.1111\/jdi.13241","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T13:15:54Z","timestamp":1582722954000},"page":"1363-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Long\u2010term efficacy of the sodium\u2013glucose cotransporter\u00a02 inhibitor, ipragliflozin, in a case of type\u00a0A insulin resistance syndrome"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-8588","authenticated-orcid":false,"given":"Shuichi","family":"Nagashima","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Medicine Jichi Medical University Shimotsuke 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