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We studied the differences in type\u00a02 diabetes and diabetic complications between northern and southern China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We carried out a cross\u2010sectional survey using data from the China Cardiometabolic Registries on blood pressure, blood lipids and blood glucose in 25,398 Chinese type\u00a02 diabetes patients. Macrovascular, microvascular and other complications were collected by self\u2010report or medical records, and then divided into the northern and southern groups by the boundary of the Yangtze River.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Northern patients were younger, and had heavier weight, greater body mass index and waist circumference, higher blood pressure, higher total cholesterol, higher low\u2010density lipoprotein cholesterol, and higher hemoglobin A1C. The prevalence of cardiovascular, cerebrovascular and macrovascular complications were 1.76\u2010fold, 1.24\u2010fold and 1.47\u2010fold more in northern than that in southern Chinese patients. In addition, the prevalence of diabetic nephropathy, retinopathy, neuropathy and microvascular complications in northern Chinese patients also increased. When stratified by age, the difference in both cardiovascular disease and ischemic stroke morbidity became significant, even in the 35\u201344\u00a0years age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More macrovascular and microvascular complications were found in northern compared with southern patients, and the largest difference also appeared in the younger age groups &lt;55\u00a0years, which might be meaningful to a screening and treatment strategy according to geographic differences.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13262","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T06:27:06Z","timestamp":1585549626000},"page":"1285-1294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Greater macrovascular and microvascular morbidity from type\u00a02 diabetes in northern compared with southern China: A cross\u2010sectional study"],"prefix":"10.1111","volume":"11","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Xijing Hospital Xi\u2019an, Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Xijing Hospital Xi\u2019an, Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinwen","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Xijing Hospital Xi\u2019an, Shaanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Xijing Hospital Xi\u2019an, Shaanxi 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