{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:14:19Z","timestamp":1775067259501,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Statins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type\u00a01 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver enzymes 6\u00a0months into atorvastatin therapy. The second patient developed liver dysfunction 8\u00a0months after the initiation of rosuvastatin therapy. Liver biopsies in both patients showed either portal, interface and lobular hepatitis or a piece\u2010meal necrosis with lymphocytes and plasma cell infiltration that were compatible with autoimmune hepatitis. Then, both patients were started on prednisolone, to which they responded well. Liver biopsy is to be considered for type\u00a01 diabetes patients if there is no improvement of liver dysfunction after discontinuation of statins.<\/jats:p>","DOI":"10.1111\/jdi.13271","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T17:58:37Z","timestamp":1586627917000},"page":"1673-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Statin\u2010induced autoimmune hepatitis in patients with type\u00a01 diabetes: A report of two cases and literature review"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-4744","authenticated-orcid":false,"given":"Eiji","family":"Kawasaki","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Shin\u2010Koga Hospital Kurume 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