{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:27:35Z","timestamp":1789637255090,"version":"4.0.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T00:00:00Z","timestamp":1590451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009158","name":"Kawasaki Medical School","doi-asserted-by":"publisher","award":["Research Project Grant 29G\u2010002"],"award-info":[{"award-number":["Research Project Grant 29G\u2010002"]}],"id":[{"id":"10.13039\/501100009158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Non\u2010alcoholic fatty liver disease (NAFLD) is often observed in individuals with type\u00a02 diabetes mellitus, and it is known that the presence of type\u00a02 diabetes mellitus leads to the aggravation of NAFLD. The aim of this study was to compare the possible effects of three kinds of oral hypoglycemic agents on NAFLD in individuals with type\u00a02 diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We carried out a prospective clinical trial (a randomized and open\u2010label study) in patients with type\u00a02 diabetes mellitus and NAFLD. A total of 98 patients were randomly allocated either to the dapagliflozin (<jats:italic>n<\/jats:italic>\u00a0=\u00a032), pioglitazone (<jats:italic>n<\/jats:italic>\u00a0=\u00a033) or glimepiride (<jats:italic>n<\/jats:italic>\u00a0=\u00a033) group, and the patients took these drugs for 28\u00a0weeks. The primary end\u2010point was the change of the liver\u2010to\u2010spleen ratio on abdominal computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in baseline clinical characteristics among the three groups. Dapagliflozin, pioglitazone and glimepiride ameliorated hyperglycemia similarly. Bodyweight and visceral fat area were significantly decreased only in the dapagliflozin group. Serum adiponectin levels were markedly increased in the pioglitazone group compared with the other two groups. Dapagliflozin and pioglitazone, but not glimepiride, significantly increased the liver\u2010to\u2010spleen ratio, and the effects of dapagliflozin and pioglitazone on the liver\u2010to\u2010spleen ratio were comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study showed that the decrease of visceral fat area and the increase of adiponectin level contributed to the improvement of NAFLD in patients with type\u00a02 diabetes mellitus. Furthermore, dapagliflozin and pioglitazone exerted equivalent beneficial effects on NAFLD in patients with type\u00a02 diabetes mellitus, although it seemed that these two drugs had different mechanisms of action.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13279","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T13:37:16Z","timestamp":1587735436000},"page":"1612-1622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["Comparison of the effects of three kinds of glucose\u2010lowering drugs on non\u2010alcoholic fatty liver disease in patients with type 2 diabetes: A randomized, open\u2010label, three\u2010arm, active control study"],"prefix":"10.1111","volume":"11","author":[{"given":"Tomoe","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Division of Diabetes, Metabolism and Endocrinology Kawasaki Medical School Kurashiki 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