{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:02:47Z","timestamp":1773046967777,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101RA) are used for treatment of type\u00a02 diabetes mellitus worldwide. However, some patients do not respond well to the therapy, and caution must be taken for certain patients, including those with reduced insulin secretory capacity. Thus, it is clinically important to predict the efficacy of GLP\u20101RA therapy. GLP\u20101R\u2010targeted imaging has recently emerged to visualize and quantify \u03b2\u2010cells. We investigated whether GLP\u20101R\u2010targeted imaging can predict the efficacy of GLP\u20101RA treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We developed <jats:sup>111<\/jats:sup>Indium\u2010labeled exendin\u20104 derivative (<jats:sup>111<\/jats:sup>In\u2010Ex4) as a GLP\u20101R\u2010targeting probe. Diabetic mice were selected from NONcNZO10\/LtJ male mice that were fed for different durations with 11% fat chow. After 3\u2010week administration of dulaglutide as GLP\u20101RA therapy, mice with non\u2010fasting blood glucose levels &lt;300\u00a0mg\/dL and &gt;300\u00a0mg\/dL were defined as responders and non\u2010responders, respectively. In addition, <jats:italic>ex\u00a0vivo<\/jats:italic> <jats:sup>111<\/jats:sup>In\u2010Ex4 pancreatic accumulations (<jats:sup>111<\/jats:sup>In\u2010Ex4 pancreatic values) were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The non\u2010fasting blood glucose levels after treatment were 172.5\u00a0\u00b1\u00a042.4\u00a0mg\/dL in responders (<jats:italic>n<\/jats:italic>\u00a0=\u00a04) and 330.8\u00a0\u00b1\u00a020.7\u00a0mg\/dL in non\u2010responders (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), respectively. <jats:italic>Ex\u00a0vivo<\/jats:italic> <jats:sup>111<\/jats:sup>In\u2010Ex4 pancreatic values showed significant correlations with post\u2010treatment glycohemoglobin and glucose area under curve during an oral glucose tolerance test (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.76 and 0.80; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and &lt;0.01, respectively). The receiver operating characteristic area under curve for identifying responders by <jats:italic>ex\u00a0vivo<\/jats:italic> <jats:sup>111<\/jats:sup>In\u2010Ex4 pancreatic values was 1.00 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Ex\u00a0vivo<\/jats:italic> <jats:sup>111<\/jats:sup>In\u2010Ex4 pancreatic values reflected dulaglutide efficacy, suggesting clinical possibilities for expanding GLP\u20101R\u2010targeted imaging applications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13281","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T07:01:49Z","timestamp":1587625309000},"page":"1448-1456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of glucagon\u2010like peptide\u20101 receptor\u2010targeted imaging probe with <i>in\u00a0vivo<\/i> glucagon\u2010like peptide\u20101 receptor agonist glucose\u2010lowering effects"],"prefix":"10.1111","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-1138","authenticated-orcid":false,"given":"Takaaki","family":"Murakami","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Radioisotope Research Center Agency of Health, Safety and Environment Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-8092","authenticated-orcid":false,"given":"Naotaka","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-2945","authenticated-orcid":false,"given":"Keita","family":"Hamamatsu","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5334-7687","authenticated-orcid":false,"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Department of Diabetes and Endocrinology Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-2593","authenticated-orcid":false,"given":"Nobuya","family":"Inagaki","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology and Nutrition Kyoto University Graduate School of Medicine Kyoto 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