{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:41:48Z","timestamp":1790001708454,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Diabetes Invest"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims\/Introduction<\/jats:title><jats:p>Sodium\u2013glucose cotransporter\u00a02 inhibitors (SGLT2i) improve renal outcome in patients with type\u00a02 diabetes mellitus, but the mechanism is not fully understood. The aim of this retrospective study was to assess the association of achieved blood pressure with renal outcomes in Japanese type\u00a02 diabetes mellitus patients with chronic kidney disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We assessed 624 Japanese type\u00a02 diabetes mellitus patients with chronic kidney disease taking SGLT2i for &gt;1\u00a0year. The patients were classified as those with post\u2010treatment mean arterial pressure (MAP) of \u226592\u00a0mmHg (<jats:italic>n<\/jats:italic>\u00a0=\u00a0344) and those with MAP of &lt;92\u00a0mmHg (<jats:italic>n<\/jats:italic>\u00a0=\u00a0280) for propensity score matching (1:1 nearest neighbor match with 0.04 of caliper value and no replacement). The end\u2010point was a composite of progression of albuminuria or a decrease in the estimated glomerular filtration rate by \u226515% per year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By propensity score matching, a matched cohort model was constructed, including 201 patients in each group. The incidence of renal composite outcome was significantly lower among patients with MAP of &lt;92\u00a0mmHg than among patients with MAP of \u226592\u00a0mmHg (<jats:italic>n<\/jats:italic>\u00a0=\u00a011 [6%] vs <jats:italic>n<\/jats:italic>\u00a0=\u00a026 [13%], respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). The change in estimated glomerular filtration rate was similar in the two groups; however, the change in the albumin\u2010to\u2010creatinine ratio was significantly larger in patients with MAP of &lt;92\u00a0mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Japanese type\u00a02 diabetes mellitus patients with chronic kidney disease, blood pressure after SGLT2i administration influences the renal composite outcome. Blood pressure management is important, even during treatment with SGLT2i.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdi.13318","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T14:30:12Z","timestamp":1591540212000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Blood pressure after treatment with sodium\u2013glucose cotransporter\u00a02 inhibitors influences renal composite outcome: Analysis using propensity score\u2010matched models"],"prefix":"10.1111","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1284-9728","authenticated-orcid":false,"given":"Kazuo","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Committee of Hypertension and Kidney Disease Kanagawa Physicians Association Yokohama Japan"},{"name":"Department of Medical Science and Cardiorenal Medicine Yokohama City University Graduate School of Medicine Yokohama 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